Results 91 to 100 of about 1,037,302 (309)

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]

, 2017
© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe, C Zhao, CJ Du, D Bakstad, D Farre, D Hartl, D Mullassery, D Xing, DA Turner, DG Spiller, E Kassi, E Munukka, ED Papadimitraki, FA Carvalho, I Caballero, JC Price, JC Price, JH Levine, K Dahlman-Wright, K Paech, KA Zarember, L Ashall, L Bjornstrom, M Junkin, M Lion, M Maggiolini, ME Quaedackers, MF Smith Jr., N Munoz, O Takeuchi, PL Zeitlin, R Galien, RC Dodel, RH Straub, S Ghisletti, S Rakoff-Nahoum, S Reardon, SK Drexler, TK Lee, WH Sun, Y Wang, Z Cai, ZX Shan   +42 more
core   +5 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Control of Hedgehog Signalling by the Cilia-Regulated Proteasome

Journal of Developmental Biology, 2016
The Hedgehog signalling pathway is evolutionarily highly conserved and essential for embryonic development of invertebrates and vertebrates. Consequently, impaired Hedgehog signalling results in very severe human diseases, ranging from holoprosencephaly ...
Christoph Gerhardt, Antonia Wiegering, Tristan Leu, Ulrich Rüther   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cobalt Protoporphyrin Improves Heart Function by Attenuating Cardiac Beta-oxidation and Restoring Redox Balance in an Animal Model of Experimental Diabetes

Frontiers in Physiology, 2012
Myocardial dysfunction and coronary macro/microvascular alterations are the hallmarks of diabetic cardiomyopathy and are ascribed to increased oxidative stress and altered nitric oxide synthase (NOS) activity.
Jian eCao, Jian eCao, Cecilia eVecoli, Cecilia eVecoli, Danilo eNeglia, Barbara eTavazzi, Giuseppe eLazzarino, Michela eNovelli, Pellegrino eMasiello, Yu-tang eWang, Nazareno ePaolocci, Nazareno ePaolocci, Nitin ePuri, Antonio eL'Abbate, Antonio eL'Abbate, Nader G. Abraham   +15 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The auxin signalling network translates dynamic input into robust patterning at the shoot apex

Molecular Systems Biology, 2011
The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time.
Teva Vernoux, Géraldine Brunoud, Etienne Farcot, Valérie Morin, Hilde Van den Daele, Jonathan Legrand, Marina Oliva, Pradeep Das, Antoine Larrieu, Darren Wells, Yann Guédon, Lynne Armitage, Franck Picard, Soazig Guyomarc'h, Coralie Cellier, Geraint Parry, Rachil Koumproglou, John H Doonan, Mark Estelle, Christophe Godin, Stefan Kepinski, Malcolm Bennett, Lieven De Veylder, Jan Traas   +23 more
doaj   +1 more source

The Signal in the Genomes

PLoS Computational Biology, 2006
Nostra culpa. Not only did we foist a hastily conceived and incorrectly executed simulation on an overworked RECOMB conference program committee, but worse—nostra maxima culpa—we obliged a team of high-powered researchers to clean up after us! It was never our intention to introduce an alternative way of constructing synteny blocks; the so-called ST ...
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source