Results 121 to 130 of about 1,037,302 (309)

Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]

, 2007
Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Brown, M., Jia, J.F., Kell, D.B., Wang, H., Yue, H.   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia

Cell Communication and Signaling
Background Small extracellular vesicles (sEVs) are critical mediators of cell communications and are influenced by cellular stress. This study investigates the role of P2X4 and P2X7 purinoreceptors in the biogenesis and release of sEVs from triple ...
Thomas Duret, Mohammed Elmallah, Audrey Heraud-Meley, Cloé Tessier, Ana Valeria Vinhais Da Silva, Stéphanie Chadet, Roxane Lemoine, Justine Gainche, Valérie Labas, Ana-Paula Teixeira-Gomes, Daniel Tomas, Vesna Cuplov, Lin-Hua Jiang, Lili Fan, Gang Yin, Christophe Baron, Sébastien Roger   +16 more
doaj   +1 more source

Religious parents receive more alloparental aid in rural Bangladesh

Evolutionary Human Sciences
Researchers have long speculated about the evolutionary benefits of religiosity. One explanation for the evolution of religious ritual is that rituals signal commitment to co-religionists.
Theodore Samore, Richard Sosis, John Shaver, Radim Chvaja, Matthew Conrad, Anushe Hassan, Robert F. Lynch, Susan Schaffnit, Laure Spake, Joseph Watts, Mary K. Shenk, Rebecca Sear, Nurul Alam   +12 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Brassinosteroid signalling [PDF]

, 2020
Kim, Eun-Ji, Russinova, Eugenia
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quantum deleting and Signalling

, 2003
It is known that if we can clone an arbitrary state we can send signal faster than light. Here, we show that deletion of unknown quantum state against a copy can lead to superluminal signalling.
Arun K Pati, Bruß, Bužek, Bužek, Bužek, Cerf, Dieks, Dirac, Duan, Duan, Feng, Ghosh, Gisin, Gisin, Gisin, Herbert, Jozsa, Landauer, Nielsen, Pati, Pati, Pati, Pati, Qiu, Samuel L Braunstein, Svetlichny, Szilard, Wootters, Yuen   +28 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source