Results 101 to 110 of about 722,278 (319)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Cancer-associated fibroblasts gene signature: a novel approach to survival prediction and immunotherapy guidance in colon cancer

Frontiers in Immunology
BackgroundFibroblasts can regulate tumour development by secreting various factors. For COAD survival prediction and CAFs-based treatment recommendations, it is critical to comprehend the heterogeneity of CAFs and find biomarkers.MethodsWe identified ...
Wenbing Zhang, Chi Yang, Ye Lu, Ye Lu, Chenling Tang, Mengyu Zhao, Zhaohui Wang, Jidong Gao, Jidong Gao, Shuangjiu Hu, Zhihua Chen   +10 more
doaj   +1 more source

A subset of co-expressed genes in Slug-based cancer mesenchymal transition signature remains coexpressed in normal samples in a tissue-specific manner

, 2012
A recently identified gene expression signature of EMT markers containing the transcription factor Slug was found present in samples from many publicly available cancer gene expression datasets of multiple cancer types except leukemia. We also found many
Weiyi Cheng, Dimitris Anastassiou
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Universality of a mesenchymal transition signature in invasive solid cancers

, 2012
In this brief communication, additional computational validation is provided consistent with the unifying hypothesis that a shared biological mechanism of mesenchymal transition, reflected by a precise gene expression signature, may be present in all ...
Dimitris Anastassiou
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

An intriguing vision for transatlantic collaborative health data use and artificial intelligence development

npj Digital Medicine
Our traditional approach to diagnosis, prognosis, and treatment, can no longer process and transform the enormous volume of information into therapeutic success, innovative discovery, and health economic performance.
Daniel C. Baumgart
doaj   +1 more source

Unique genetic signatures in HIV-1 subtype A1 and A1D recombinant envelope glycoprotein distinguish contemporary transmitted/founder viruses from historical strains in East Africa

Frontiers in Microbiology
IntroductionThe envelope glycoprotein (Env) of HIV-1 Transmitted/Founder (T/F) viruses in subtypes B and C carries distinct genetic signatures that enhance transmission fitness, augment infectivity and immune evasion.
Frank Kato, Frank Kato, Anne Kapaata, Ronald Galiwango, Ronald Galiwango, Angella Nakyanzi, Christian Ndekezi, Christian Ndekezi, Fortunate Natwijuka, Fortunate Natwijuka, Denis Omara, Denis Omara, Andrew Ekii Obuku, Brian Foley, Pontiano Kaleebu, Pontiano Kaleebu, Eunice Nduati, Sheila Nina Balinda, Sheila Nina Balinda   +18 more
doaj   +1 more source

Estimation of the sky radiance [PDF]

Scientific Technical Review, 2019
For the infrared prefilter model there was a need for testing the sky radiation and defining its fluctuations within the zone of neighborhood area for the current frame and tests of repeatability.
Knežević Dragan, Nikolić Zoran, Mišković Katarina, Vasiljević Darko   +3 more
doaj  

THE ELECTRONIC SIGNATURE. ITS VALORIZATION AS A EVIDENTIARY MEANS IN NATIONAL OR INTERNATIONAL PENDING CASES JUDGED IN COURTS [PDF]

In the European Union states, there is a variety of legal norms regulating the electronic signature, fact which led to the initiative of the European Commission to harmonize the incidental dispositions in the legislation of the member states to eliminate
. George Măgureanu
core