Results 161 to 170 of about 488,795 (269)

Predicting prognosis and drug sensitivity in patients with hepatocellular carcinoma using an lncRNA signature associated with cuproptosis. [PDF]

BMC Cancer
Li Y, Lv S, Wang Y.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Minimally Invasive Aortic Regurgitation Surgery

JACC: Basic to Translational Science
Jinyun Zhu, PhD, MD, Chen Gao, PhD, Yibin Wang, PhD   +2 more
doaj   +1 more source

Inaccurate interpretation of hypoxia signatures from transcriptomic analyses in neuro-oncology. [PDF]

Neoplasia
Simmons RK, Raut P, Younes ST, Gallo M.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Integrated transcriptomic and lipidomic analyses reveal altered lipid homeostasis in mutant FUS P525L astrocytes from HiPSCs

Journal of Translational Medicine
Yingli Zhu, Jingxiu Huang, Katrien Neyrinck, Mingkang Liu, Tianyi Yang, Karan Ahuja, Yoke Chin Chai   +6 more
doaj   +1 more source

Prognostic Biomarker Signature of Relapse in Neuromyelitis Optica Spectrum Disorders in the CIRCLES Observational Study. [PDF]

Neurol Neuroimmunol Neuroinflamm
Bach E, Breschi A, Wang Y, Carroll MK, Luk W, Han A, Short S, Cimermančič P, Drake KA, Cook LJ, Snyder T, Smith TJ, Yeaman MR, Kim CC, Guthy-Jackson Charitable Foundation CIRCLES Study Group.   +14 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

A RAIR-ATC transcriptional axis and multimodal drug-response modelling reveal class-level vulnerabilities in thyroid cancer. [PDF]

Front Pharmacol
Wang S, Zhang D, Liu W, Zhu M, Li R, Liu Z, Wu P, Liu T.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source