Results 151 to 160 of about 2,249,719 (290)

A Five-Biomarker IHC-Based Signature Predicting Outcome in Breast Cancer Patients Following Adjuvant Anthracycline-Based Chemotherapy. [PDF]

Cancers (Basel)
Wang S, Gilmore E, Umbreen S, Fines C, Burden R, McQuaid S, Buckley N.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Integrating bulk, single-cell, and spatial transcriptomics to identify a novel pyroptosis-related gene signature for predicting prognosis and tumor immune landscape in triple-negative breast cancer. [PDF]

Front Immunol
Xiang L, Rao J, Ma A, Zhang Y, Li C, Xie T, Xue H, Chen Z, Liu T, Yuan J, Yan H.   +10 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization. [PDF]

NPJ Cardiovasc Health
Zhao JV, Sarsani V, Chen B, Yun H, Hu J, Liang L.   +5 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A comprehensive multi-omics and functional study of evolutionary adaptive responses to smoke. [PDF]

iScience
Pouwels SD, Chen H, Rathnayake SNH, Lan A, Mahbub RM, Yeung ACY, Brandsma CA, Lobo TJ, Guryev V, Heijink IH, van den Berge M, Faiz A.   +11 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Effects of a 24-week resistance exercise program on Alzheimer's disease brain signatures in cognitively unimpaired older adults: a secondary analysis of the AGUEDA randomized controlled trial. [PDF]

Age Ageing
Sanchez-Martinez J, Solis-Urra P, Fernandez-Gamez B, Fernández-Ortega J, Sánchez-Aranda L, Erickson KI, Ortega FB, Esteban-Cornejo I.   +7 more
europepmc   +1 more source