Results 71 to 80 of about 146,402 (261)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Sentiment Analysis Based on Heterogeneous Multi-Relation Signed Network
MathematicsExisting sentiment prediction methods often only classify users’ emotions into a few categories and cannot predict the variation of emotions under different topics.
Qin Zhao +4 more
doaj +1 more source
Evolution of human signed networks [PDF]
Advances in Methodology and Statistics, 2004 Two strands of empirical research were based on Heider’s work. One was experimental and remained true to idea that mental affect processes operating within human actors are central while the other jumped to the level of group dynamics and relegated the mental affect processes to the status of background phenomena. By the 1980s, both strands had petered
openaire +3 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
More on Spectral Analysis of Signed Networks
Complexity, 2018 Spectral graph theory plays a key role in analyzing the structure of social (signed) networks. In this paper we continue to study some properties of (normalized) Laplacian matrix of signed networks. Sufficient and necessary conditions for the singularity
Guihai Yu, Hui Qu
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Rewiring driven evolution of quenched frustrated signed network
Journal of Physics: ComplexityA framework for studying the behavior of a classically frustrated signed network in the process of random rewiring is developed. We describe jump probabilities for change in frustration and formulate a theoretical estimate in terms of the master equation.
Sven Benjamin Kožić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source