Results 61 to 70 of about 146,402 (261)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Polarity related influence maximization in signed social networks. [PDF]

PLoS ONE, 2014
Influence maximization in social networks has been widely studied motivated by applications like spread of ideas or innovations in a network and viral marketing of products.
Dong Li, Zhi-Ming Xu, Nilanjan Chakraborty, Anika Gupta, Katia Sycara, Sheng Li   +5 more
doaj   +1 more source

Signed Networks: theory, methods, and applications

Signed networks provide a principled framework for representing systems in which interactions are not merely present or absent but qualitatively distinct: friendly or antagonistic, supportive or conflicting, excitatory or inhibitory. This polarity reshapes how we think about structure and dynamics in complex systems: a negative tie is not simply a ...
Diaz-Diaz, Fernando, Candellone, Elena, González-Casado, Miguel, Fraxanet, Emma, Vendeville, Antoine, Ferri, Irene, Teixeira, Andreia   +6 more
openaire   +4 more sources

Information diffusion in signed networks

PLOS ONE, 2019
Information diffusion has been widely discussed in various disciplines including sociology, economics, physics or computer science. In this paper, we generalize the linear threshold model in signed networks consisting of both positive and negative links.
Xiaochen He, Haifeng Du, Marcus W. Feldman, Guangyu Li   +3 more
openaire   +4 more sources

Disagreement in Signed Financial Networks [PDF]

, 2018
We extend the study of rate of convergence to consensus of autonomous agents on an interaction network. In particular, we introduce antagonistic interactions and thus a signed network. This will allow to include the, previously discarded, sign information, in the analysis of disagreement on statistical financial ...
Monica Billio, Roberto Casarin, Michele Costola, Lorenzo Frattarolo   +3 more
openaire   +3 more sources

Measuring partial balance in signed networks [PDF]

Journal of Complex Networks, 2017
Peer-reviewed author copy, 31 pages, 6 figures, 5 ...
Samin Aref, Mark C. Wilson
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

SignedLouvain: Louvain for signed networks

CoRR
In this article, we consider the problem of community detection in signed networks. We propose SignedLouvain, an adaptation of the Louvain method to maximise signed modularity, efficiently taking advantage of the structure induced by signed relations. We begin by identifying the inherent limitations of applying the standard Louvain algorithm to signed ...
John N. Pougué-Biyong, Renaud Lambiotte
openaire   +3 more sources