Results 41 to 50 of about 2,851 (249)

Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids

Nature Communications
Brain organoids have been proposed as suitable human brain model candidates for a variety of applications. However, the lack of appropriate maturation limits the transferability of such functional tools.
Honghui Zheng, Yilin Feng, Jiyuan Tang, Feifei Yu, Zitian Wang, Jiani Xu, Cheng Hai, Mingyue Jiang, Yifan Cheng, Zhicheng Shao, Ning Ma, Peter E. Lobie, Shaohua Ma   +12 more
doaj   +1 more source

Meta-Structure Surface Based on Dielectric Tensor Rotation Induced by AC Electric Field for Insulation Improvement

Frontiers in Materials, 2022
Electric field distribution along gas–solid interfaces determines the reliability of insulating components. However, the dielectric gradient insulating component prepared by the conventional method is considered to only control the internal electric ...
Zikui Shen, Zikui Shen, YanPeng Hao, Zhenyu Xin, Xilin Wang, Zhidong Jia   +5 more
doaj   +1 more source

SIG on Telepresence Robots

Extended Abstracts of the 2018 CHI Conference on Human Factors in Computing Systems, 2018
In this document we explain the need and plans for a SIG Meeting at CHI on telepresence robots. We describe the organization of this SIG, our expected attendees, procedure and schedule of topics to be discussed, as well as our recruitment plan. Our goal is to provide a forum to discuss key issues surrounding the uses and usefulness of telepresence ...
Houda el Mimouni, Susan R. Fussell, Susan Herring, Carman Neustaedter, Jennifer A. Rode   +4 more
openaire   +3 more sources

Visualizing knowledge domains. Sponsored by SIG CR, SIG VIS [PDF]

Proceedings of the American Society for Information Science and Technology, 2002
AbstractInformation visualization can be a powerful tool for simplifying access to complex material. This panel will explore the use of visualization techniques to organize and display the structure of knowledge in subject domains, and the extent to which it is successful in clarifying the scope of individual fields and the relationships between ...
Edie Rasmussen, Helen Barsky Atkins, Katy Börner, Katherine W. McCain   +3 more
openaire   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Microdroplet-Engineered Skeletal Muscle Organoids from Primary Tissue Recapitulate Parental Physiology with High Reproducibility

Research
Achieving high maturity and functionality in in vitro skeletal muscle models is essential for advancing our understanding of muscle biology, disease mechanisms, and drug discovery.
Jiawei Li, Yiming Yang, Ziqi Yi, Yu Zhu, Haowei Yang, Baiming Chen, Peter E. Lobie, Shaohua Ma   +7 more
doaj   +1 more source

How is image seeking and use studied: Theoretical models and research methods: Sponsored by: SIG VIS, SIG AH, SIG DL, and SIG USE [PDF]

Proceedings of the Association for Information Science and Technology, 2016
ABSTRACT The digital revolution is associated with the proliferation of visual resources and with the increasing use of images in teaching, scholarly activities, communication, and everyday information practices. Visual information seeking and use is a growing area of research in information science. The panel discussion will focus on
Krystyna K. Matusiak, Abebe Rorissa, Dan E. Albertson, JungWon Yoon 0003   +3 more
openaire   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Cascade Pumping Overcomes Hydraulic Resistance and Moderates Shear Conditions for Slow Gelatin Fiber Shaping in Narrow Tubes

iScience, 2020
Summary: In microextrusion-based 3D bioprinting, shaping gel fibers online, i.e., in narrow tubes, benefits the structural maintenance after extrusion, but it is challenging for materials possessing slow sol-gel transition dynamics. Gelatin, for example,
Yuanxiong Cao, Haoran Zhao, Zhiwei Hu, Shaohua Ma   +3 more
doaj   +1 more source

Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses. [PDF]

PLoS ONE, 2008
S. aureus is a highly successful pathogen that is speculated to be the most common cause of human disease. The progression of disease in S. aureus is subject to multi-factorial regulation, in response to the environments encountered during growth.
Lindsey N Shaw, Catharina Lindholm, Tomasz K Prajsnar, Halie K Miller, Melanie C Brown, Ewa Golonka, George C Stewart, Andrej Tarkowski, Jan Potempa   +8 more
doaj   +1 more source