Results 171 to 180 of about 9,248 (216)

Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension

New England Journal of Medicine, 2005
Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung.In this double-blind, placebo-controlled study, we randomly assigned 278 patients with ...
GALIE', NAZZARENO, Ghofrani, Hossein A., Torbicki, Adam, Barst, Robyn J., Rubin, Lewis J., Badesch, David, Fleming, Thomas, Parpia, Tamiza, Burgess, Gary, BRANZI, ANGELO, Grimminger, Friedrich, Kurzyna, Marcin, Simonneau, Gérald   +12 more
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Sildenafil citrate-Associated priapism

Urology, 2000
We report the first case of priapism associated with the use of sildenafil citrate. The patient was a 28-year-old man with mild erectile dysfunction after penile trauma who self-treated with a 100-mg dose of sildenafil citrate, resulting in low-flow priapism. After aspiration and intracorporal injection of alpha-agonists, the priapism resolved.
R L, Sur, C J, Kane
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Sildenafil citrate (Viagra)

Intensive and Critical Care Nursing, 1999
Sildenafil is the first of a series of orally active treatments for MED which has resulted in unprecedented demand for treatment and potentially high cost to the NHS. Further oral therapies are likely to follow in the next year or so. In clinical trials, sildenafil produced an erection (sufficient to achieve intercourse) lasting up to 4 h on around 70%
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Sildenafil citrate (Viagra(R))

Drugs of Today, 2000
Sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type V (PDE V), initially designated as compound 92-480-10 by Pfizer, was studied in the late 1980s as an antianginal. An unexpected side effect of the early clinical investigations was improved erectile function among the men studied.
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Sildenafil citrate: A therapeutic update

Clinical Therapeutics, 2001
Since its approval by the US Food and Drug Administration in March 1998, sildenafil citrate has been used by millions of men for the treatment of erectile dysfunction. Recent studies and consensus reports have expanded our understanding of its efficacy, safety, contraindications, and drug interactions.This paper reviews recent studies of the efficacy ...
E G, Boyce, E M, Umland
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Physicochemical Properties of Sildenafil Citrate (Viagra) and Sildenafil Base

Journal of Pharmaceutical Sciences, 2003
Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 A; b = 11.95 A; c = 16.68 A; beta = 106.97 degrees. [II]: a = 8.66 A; b = 34.27 A; c = 8.93 A;
Melnikov, P., Corbi, P. P., Cuin, A., Cavicchioli, M., Guimaraes, W. R.   +4 more
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Overall cardiovascular profile of sildenafil citrate

The American Journal of Cardiology, 1999
Sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5), is the first in a new class of orally effective treatments for erectile dysfunction. During sexual stimulation, the cavernous nerves release nitric oxide (NO), which induces cyclic guanosine monophosphate (cGMP) formation and smooth muscle relaxation in the corpus cavernosum ...
R M, Zusman, A, Morales, D B, Glasser, I H, Osterloh   +3 more
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SILDENAFIL CITRATE AFTER RADICAL RETROPUBIC PROSTATECTOMY

Journal of Urology, 1999
Erectile dysfunction continues to be a significant problem for men after radical retropubic prostatectomy despite nerve sparing techniques. Sildenafil citrate (Viagra) has proved effective for erectile dysfunction in many men. We determine the efficacy of sildenafil in men with erectile dysfunction after radical retropubic prostatectomy and examine ...
B H, Lowentritt, P T, Scardino, B J, Miles, F J, Orejuela, E C, Schatte, K M, Slawin, S P, Elliott, E D, Kim   +7 more
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Acute Myocardial Infarction After Sildenafil Citrate Ingestion

Annals of Pharmacotherapy, 2005
OBJECTIVE To report a case of acute myocardial infarction (MI) associated with the use of oral sildenafil in a nitrate-free patient. CASE SUMMARY A 45-year-old man was admitted to the hospital with acute left-sided chest pain, nausea, and vomiting that started approximately 30 minutes after taking sildenafil 100 mg before a sexual contact.
KEKİLLİ, MURAT, BEYAZIT, YAVUZ, Purnak, T, Dogan, S, Atalar, E   +4 more
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FIA of sildenafil citrate using UV-detection

Journal of Pharmaceutical and Biomedical Analysis, 2001
A flow injection analysis (FIA) of sildenafil citrate (SLD) using UV detection is described in this study. The best solvent system was found to be consisting of 0.2 M phosphate buffer at pH 8 having 10% MeOH. A flow rate of 1 ml. min(-1) was pumped and active material was detected at 292 nm.
Altıokka, Göksel, Atkoşar, Zeki, Şener, E, Tunçel, Muzaffer   +3 more
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