Results 131 to 140 of about 1,711 (245)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

ADMINISTRATIVE SILENCE

open access: yes, 2016
Odlučujući o upravnoj stvari, javnopravno tijelo donosi rješenje, ali ako ovlašteno tijelo ne odluči o upravnoj stvari u zakonom propisanom roku, tada se govori o šutnji administracije, odnosno šutnji uprave.
Badanjak, Tihana
core  

Detectives and disclosure: an analysis of the implementation of the disclosure provisions of the criminal procedure and investigations act 1996 by cm officers, based on a study of operational procedure in two police force areas [PDF]

open access: yes, 2002
The Criminal Procedure and Investigations Act 1996 introduced new procedures for the handling of unused material in criminal cases. Defective treatment of such material has been a central aspect of many of the most notorious miscarriages of justice of ...
Taylor, Christopher William
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

El Silencio Administrativo y sus Matices a la Luz de la Legislación y la Jurisprudencia en un Estado Social de Derecho

open access: yesJusticia, 2008
Para brindarles a los particulares medios idóneos para su desenvolvimiento en la sociedad, el constituyente a través del artículo 23 de la Carta Política actual, elevado a derecho fundamental, le otorga a las personas la posibilidad de impulsar la ...
Fabio César Amorocho Mart   +1 more
doaj  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

The state of fundamental legal rights in Australia [PDF]

open access: yes, 2014
Executive summary: This report demonstrates that a serious problem exists with respect to fundamental legal rights in Australian law. Our research has focussed on the extent to which four such fundamental legal rights are abrogated in current acts of the
Simon Breheny
core  

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