Results 21 to 30 of about 36,922 (259)

Resveratrol alleviates lipopolysaccharide-induced inflammation in PC-12 cells and in rat model

open access: yesBMC Biotechnology, 2019
Background Spinal cord injury (SCI) remains a huge medical problem nowadays as there is no hospital providing the versatile strategies for repairing central nervous system and restoring function. Herein, we focused on PC-12 cells as an important research
Guiqi Zhang   +5 more
doaj   +1 more source

In vivo CD40 Silencing by siRNA Infusion in Rodents and Evaluation by Kidney Immunostaining

open access: yesBio-Protocol, 2021
The co-stimulatory molecule CD40 and its ligand CD40L play a key role in the regulation of immunological processes and are involved in the pathophysiology of autoimmune and inflammatory diseases.
Miguel Hueso   +12 more
doaj   +1 more source

El silencio en el maestro

open access: yesRevista Española de Pedagogía
Only by analyzing the idea of silence we can include this attitude among the virtues of those who perform the teaching function. The doctor García Hoz defines silence as the absence of every useless word. The idea of silence is justified in the teaching
Víctor García Hoz
doaj   +1 more source

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

open access: yesMolecular Therapy: Nucleic Acids, 2016
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expression ...
Justin B Lee   +13 more
doaj   +1 more source

α-Fetoprotein promoter-driven Cre/LoxP-switched RNA interference for hepatocellular carcinoma tissue-specific target therapy. [PDF]

open access: yesPLoS ONE, 2013
RNA interference (RNAi) has recently emerged as a potential treatment modality for hepatocellular carcinoma (HCC) therapy, but the lack of cellular targets and sustained efficacy limits its application.
Yuan-Fei Peng   +9 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

Courting, Criticism, Censorship and Bombs

open access: yesNordicom Review, 2006
On the eve of the conflict in Iraq, the US administration tried to re-establish more friendly relations with the Arab media. This article reviews American public diplomacy and communications strategies towards the Arab satellite networks, with particular
Figenschou Tine Ustad
doaj   +1 more source

Forward Precision Medicine: Micelles for Active Targeting Driven by Peptides

open access: yesMolecules, 2021
Precision medicine is based on innovative administration methods of active principles. Drug delivery on tissue of interest allows improving the therapeutic index and reducing the side effects.
Filippo Prencipe   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

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