Results 141 to 150 of about 400,021 (291)

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

A silenced suppressor [PDF]

Nature Reviews Cancer, 2005
openaire   +1 more source

Promoting virus-induced gene silencing of pepper genes by a heterologous viral silencing suppressor. [PDF]

Plant Biotechnol J, 2021
Zhou Y, Deng Y, Liu D, Wang H, Zhang X, Liu T, Wang J, Li Y, Ou L, Liu F, Zou X, Ouyang B, Li F.   +12 more
europepmc   +1 more source

Adaptive Supramolecular Interactions Govern Redox‐Active Molecules in Aqueous Redox Flow Batteries

Advanced Materials, EarlyView.
Adaptive supramolecular interactions overcome the solubility‐stability trade‐off in aqueous redox flow batteries. Hydrophobic anions disrupt intrinsic π–π stacking to enable high solubility, while redox‐state‐dependent spin pairing and cation coordination dynamically stabilize reactive intermediates during operation.
Vikram Singh, Seongyeon Kwon, Giu A. Silva Testa, Ariyeong Yun, Yohan Kim, Yunseop Choi, Dongwook Kim, Seongmo Ahn, Minyoung Shim, Jongcheol Seo, Evan Wenbo Zhao, Mu−Hyun Baik, Hye Ryung Byon   +12 more
wiley   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

, 2003
We attempted to answer two central questions about epigenetic silencing of the tumor suppressor gene p16INK4a in this study: (1) whether the maintenance of associated histone modifications is dependent on DNA methylation and (2) whether such histone ...
Rhee, Ina, Rajagopalan, Harith, Herman, James G, Baylin, Stephen B, Bachman, Kurtis E, Vogelstein, Bert, Park, Ben Ho, Kinzler, Kenneth W   +7 more
core   +1 more source

Begomoviral pre-coat protein boosts potato virus X in mixed infection through interfering with antiviral RNAi response

Virology Journal
Background Plant-infecting viruses cause severe crop losses throughout the world. The frequent occurrence of mixed infection (co-existence of multiple viruses in a single infected plant) in the field makes the situation more alarming.
Dibyendu Ghosh, M. Malavika, Pratibha Rawat, Supriya Chakraborty   +3 more
doaj   +1 more source

Identification and characterization of a new geminivirus from soybean plants and determination of V2 as a pathogenicity factor and silencing suppressor. [PDF]

BMC Plant Biol, 2022
Li Q, Zhang Y, Lu W, Han X, Yang L, Shi Y, Li H, Chen L, Liu Y, Yang X, Shi Y.   +10 more
europepmc   +1 more source

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

Advanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola, Tamara Fawzi, Emma H. Kromann, Marion Leleu, Joanna M. Drelinkiewicz, Dusko Ilic, Cécile A. Dreiss, Joana F. Neves, Eileen Gentleman   +8 more
wiley   +1 more source

Shallot virus X p42 Protein Expressed in Concert with Virus Movement Proteins Is a Suppressor of Two Plant Antiviral Defense Mechanisms

Plants
The genomes of viruses in the Allexivirus genus encode the p42 protein, which is considered the hallmark of the genus. The functions of p42 have not yet been studied experimentally and cannot be predicted based on sequence similarity, as p42-related ...
Denis A. Chergintsev, Alexander A. Lezzhov, Ekaterina A. Lazareva, Anastasia K. Atabekova, Anna D. Solovieva, Sergey Y. Morozov, Andrey G. Solovyev   +6 more
doaj   +1 more source