Results 261 to 270 of about 400,021 (291)
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Analysis of siRNA-Suppressor of Gene Silencing Interactions
2008RNA silencing is an evolutionarily conserved system that functions as an antiviral mechanism in higher plants and animals. To counteract RNA silencing, viruses evolved silencing suppressors that interfere with siRNA guided RNA silencing pathway. We used the heterologous Drosophila in vitro embryo RNA to analyze the molecular mechanism of suppression of
Lóránt, Lakatos, József, Burgyán
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CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma
Liver International, 2014AbstractBackgroundChromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a potent tumour suppressor by acting as a master regulator of a tumour‐suppressive network. Its inactivation resulted from aberrant methylation in the promoter occurs in several types of human malignancy and is associated with malignant tumour behaviour.
Rui, Zhao +4 more
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Characterization of Plant Virus-Encoded Gene Silencing Suppressors
2012Agroinfiltration assay using green fluorescent protein (GFP)-expressing Nicotiana benthamiana line 16c is a powerful method for screening of putative plant virus-encoded gene silencing suppressors. This method allows the investigator to know whether the putative viral suppressor inhibits silencing in a cell (local silencing) and/or spreading of ...
Hajime, Yaegashi +2 more
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CHD5, a tumor suppressor that is epigenetically silenced in lung cancer
Lung Cancer, 2012Chromodomain helicase DNA binding protein 5 (CHD5) is a potent tumor suppressor that serves as a master regulator of a tumor-suppressive network. Examination of the role played by CHD5 in a wide range of human cancers is warranted. In this study, we focused on the epigenetic modification and tumor-suppressive role of CHD5 in lung cancer.
Rui, Zhao +6 more
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Crystal structure of p19 ? a universal suppressor of RNA silencing
Trends in Biochemical Sciences, 2004RNA silencing in plants has an antiviral role and, consequently, plant viruses encode counter-defensive suppressor proteins that block this process. The recently reported crystal structure of two Tombusvirus suppressor proteins reveals a novel RNA-binding structure and illustrates precisely how the silencing mechanism is blocked.
David C, Baulcombe, Attila, Molnár
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Epigenetic Silencing of Tumor Suppressor Genes in Pancreatic Cancer
Journal of Gastrointestinal Cancer, 2011Without any alteration of DNA sequence, heritable changes in gene expression, caused by epigenetic pathways, are gaining a spotlight in research of diseases, and in particular, cancer. Although the dominant paradigm in cancer research, proposed by Vogelstein, suggested that cancer progression was caused by a sequential accumulation of genetic ...
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Gunshot Residue Deposition With and Without Firearm Suppressors (Silencers)
American Journal of Forensic Medicine & PathologyAbstract Forensic pathologists recognize the importance of estimating the range of fire for gunshot entrance wounds. Classically described ranges of fire include contact, close range, medium (or intermediate) range, and indeterminate (or distant) range.
Samuel P, Prahlow +2 more
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RNA Silencing and Viral Encoded Silencing Suppressors
2011Masato Ikegami +2 more
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Identification and Characterization of Silencing Suppressors in Arabidopsis
2013Post-transkriptionelles gene silencing (PTGS) kann ein limitierender Faktor für die Expression von Transgenen sein. Transgene mRNAs können von der RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) erkannt werden, was die Synthese doppelsträngiger RNA (dsRNA) initiiert und die Akkumulation von small interfering RNAs (siRNAs) zur Folge hat.
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