Results 241 to 250 of about 211,621 (304)

A Cholesterol Analogue for Cell‐Surface Enzyme Display

open access: yesAngewandte Chemie, EarlyView.
We report a non‐genetic strategy for bacterial cell surface enzyme immobilisation using cholesterol‐based artificial lipids containing Ni2+‐NTA binding groups that can integrate into biological membranes. The engineered cells can capture His‐tagged enzymes directly from cell lysates while preserving intracellular and surface activity, allowing for ...
Vasco F. Batista   +3 more
wiley   +2 more sources

Injectable Bone Cements: A Generational Framework for Bioactivity, Porosity, and Mechanobiological Design at the Nanoscale

open access: yesAdvanced NanoBiomed Research, EarlyView.
Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei   +2 more
wiley   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

open access: yesAngewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho   +9 more
wiley   +2 more sources

Catalyst Hide‐and‐Seek Beneath Porous Support Surfaces: Pinpointing Active Site Distribution Through Resonance Energy Transfer

open access: yesAngewandte Chemie, EarlyView.
Like a shark playing hide‐and‐seek in a coral reef, energy transfer (ET) finds hidden “fish” catalysts in the porous support “reef.” ET allows catalytic species to be precisely mapped, revealing whether they reside near the surface, deep in the pores, or are uniformly distributed. This approach ensures controlled catalyst distribution, highlighting how
Buddhima K. P. Maldeni Kankanamalage   +8 more
wiley   +2 more sources

Development of Sub‐50 nm Core–Shell Silica Nanoparticles With Controlled In Vivo Behavior for 19F Magnetic Resonance Imaging

open access: yesAngewandte Chemie, EarlyView.
Ultrasmall PFCE‐loaded silica nanoparticles synthesized through a one‐pot double‐emulsion synthesis method, where rapid silica shell formation kinetically fixes droplet size. The resulting s‐FLAME nanoparticles enable strong 19F MRI signals with enhanced hepatic clearance rate and tumor‐accumulation performance. ABSTRACT 19F magnetic resonance imaging (
Yue Wu   +2 more
wiley   +2 more sources

3‐Deoxy‐3‐Fluoro Mannuronic Acid Alginates: Stereoselective Automated Synthesis and Conformational Behaviour

open access: yesAngewandte Chemie, EarlyView.
The impact of C‐3 fluorination on the synthesis and conformation of alginate oligosaccharides is investigated. A C‐3‐fluoro mannuronic acid building block is generated and shown to react with high β‐selectivity. Automated glycan assembly enables access to uniquely fluorinated mannuronic acid alginates where deoxyfluorination is shown not to perturb the
Sean T. Evans   +10 more
wiley   +2 more sources

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