Results 191 to 200 of about 28,331 (250)

Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment

open access: yesJournal of Controlled Release, 2023
Silicosis is a serious silica-induced respiratory disease for which there is currently no effective treatment. Irreversible pulmonary fibrosis caused by persistent inflammation is the main feature of silicosis.
Jiantao Jiang   +2 more
exaly   +2 more sources

From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis

open access: yesInternational Journal of Molecular Sciences, 2023
Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis of silicosis in order to identify preventive or therapeutic antifibrotic ...
Shi Chen
exaly   +2 more sources

New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis

open access: yesInternational Journal of Molecular Sciences, 2021
Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar ...
Daniela Mokrá
exaly   +2 more sources

Silicosis

The Lancet, 2012
Silicosis is a fibrotic lung disease caused by inhalation of free crystalline silicon dioxide or silica. Occupational exposure to respirable crystalline silica dust particles occurs in many industries. Phagocytosis of crystalline silica in the lung causes lysosomal damage, activating the NALP3 inflammasome and triggering the inflammatory cascade with ...
Chi Chiu, Leung   +2 more
openaire   +2 more sources

Silicosis in the 1990s

Chest, 1997
To describe state-based surveillance for silicosis that estimates prevalence of this condition, describes characteristics of affected individuals, and targets public health interventions.The data presented are a case series of patients with silicosis reported to a state health department.
K D, Rosenman   +3 more
openaire   +2 more sources

SILICOSIS

Clinics in Chest Medicine, 1992
Silicosis is an ancient disease, but with modern understanding of safe levels of exposure, it should be a vanishing disease. Emphasis will be placed on newer concepts in the pathogenesis of the disease and the health effects of low levels of quartz dust in relation to current exposure standards.
openaire   +2 more sources

Senescent endothelial cell-derived Galectin 3 promotes silicosis through endothelial-fibroblast and endothelial-macrophage crosstalk.

Journal of Hazardous Materials
Silicosis is an occupational and irreversible interstitial lung disease, which is caused by the inhalation of respirable crystalline silica. Recent studies suggested that the senescence of endothelial cells is implicated in the pathogenesis of lung ...
Demin Cheng   +7 more
semanticscholar   +1 more source

Atractylenolide III Ameliorated Autophagy Dysfunction via Epidermal Growth Factor Receptor-Mammalian Target of Rapamycin Signals and Alleviated Silicosis Fibrosis in Mice.

Laboratory investigation; a journal of technical methods and pathology, 2023
Atractylenolide III (ATL-III) is a major active constituent of the natural plant Atractylodes rhizome. Our previous study has shown that ATL-III may alleviate alveolar macrophage apoptosis via the inhibition of the mammalian target of rapamycin (mTOR ...
Shiyi Tan   +6 more
semanticscholar   +1 more source

Silicosis and autoimmunity

Current Opinion in Allergy & Clinical Immunology, 2017
Purpose of reviewOf the various environmental, occupational, and medical substances that cause dysregulation of autoimmunity, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review.Recent findingsWith respect to silica, many epidemiological studies have shown a significant association between silica ...
Suni, Lee   +4 more
openaire   +2 more sources

Celastrol as a candidate drug for silicosis: From bioinformatics and network pharmacology to experimental validation.

International Immunopharmacology, 2023
Silicosis, a highly lethal occupational respiratory disease characterized by irreversible pulmonary fibrosis, remains challenging to treat due to its unclear pathogenesis.
Chao Liang   +9 more
semanticscholar   +1 more source

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