Results 71 to 80 of about 50,422 (305)

Miners, silica and disability : the bi-national interplay between South Africa and the United Kingdom, c1900-1930s [PDF]

open access: yes, 2015
This paper investigates silicosis as a disabling disease in underground mining in the United Kingdom (UK) before Second World War, exploring the important connections between South Africa and the UK and examining some of the issues raised at the 1930 ...
McIvor, Arthur
core   +1 more source

Predictors of silicosis and variation in prevalence across mines among employed gold miners in South Africa

open access: yesBMC Public Health, 2020
Background The stated intention to eliminate silicosis from the South African goldmining industry as well as current programmes to find and compensate ex-miners with silicosis require an understanding of variation in silicosis prevalence across the ...
Dave Knight   +5 more
doaj   +1 more source

Long-Term Efficacy of Pulmonary Rehabilitation in Patients with Occupational Respiratory Diseases [PDF]

open access: yes, 2012
Background: Pulmonary rehabilitation is a well-recognized treatment option in chronic obstructive lung disease improving exercise performance, respiratory symptoms and quality of life.
Jörres, Rudolf A.   +5 more
core   +1 more source

RAB20 deficiency promotes the development of silicosis via NLRP3 inflammasome

open access: yesFrontiers in Immunology, 2022
Silicosis is a worldwide serious occupational disease that is caused by inhalation of silica crystals. However, little is known about the pathogenesis mechanism of silicosis. We performed single-cell sequencing in bronchoalveolar lavage fluid (BALF) from
Zhouyangfan Peng   +4 more
doaj   +1 more source

Association between Crystalline Silica Dust Exposure and Silicosis Development in Artificial Stone Workers

open access: yesInternational Journal of Environmental Research and Public Health, 2021
Occupational exposure to respirable crystalline silica (SiO2) is one of the most common and serious risks because of the health consequences for the workers involved. Silicosis is a progressive, irreversible, and incurable fibrotic lung disease caused by
M. Requena-Mullor   +5 more
semanticscholar   +1 more source

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study. [PDF]

open access: yes, 2019
ObjectivesIn a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.MethodsWe systematically
Chu, Minjie   +16 more
core  

Endothelial‐Derived CCL7 Promotes Macrophage Polarization and Aggravates Septic Acute Lung Injury via CCR1‐Mediated STAT1 Succinylation

open access: yesAdvanced Science, EarlyView.
During sepsis, pulmonary vascular endothelial cells secrete chemokine CCL7, which plays a pivotal role in facilitating the infiltration of C‐C motif chemokine receptor 1‐positive (CCR1+) macrophages into lung tissue. Activation of the CCL7–CCR1 axis enhances the succinylation of STAT1 mediated by KAT2A, thereby driving metabolic reprogramming and ...
Xue Li   +5 more
wiley   +1 more source

Tuberculosis and Silicosis Burden in Artisanal and Small-Scale Gold Miners in a Large Occupational Health Outreach Programme in Zimbabwe

open access: yesInternational Journal of Environmental Research and Public Health, 2021
Artisanal and small-scale miners (ASMs) labour under archaic working conditions and are exposed to high levels of silica dust. Exposure to silica dust has been associated with an increased risk of tuberculosis and silicosis.
D. Moyo   +13 more
semanticscholar   +1 more source

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

open access: yesMed Research, EarlyView.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan   +4 more
wiley   +1 more source

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