Results 51 to 60 of about 28,331 (250)

Research progress on role of programmed cell death in silicosis and its possible mechanisms

环境与职业医学, 2023
Silicosis is a common occupational disease caused by long-term inhalation of large amounts of free SiO2 dust and deposition in lung tissues, characterized by the formation of silicon nodules and diffuse fibrosis of lung tissues.
Jing WU, Xue YI, Jie WANG
doaj   +1 more source

Animal models of silicosis: fishing for new therapeutic targets and treatments

European Respiratory Review, 2023
Silicosis as an occupational lung disease has been present in our lives for centuries. Research studies have already developed and implemented many animal models to study the pathogenesis and molecular basis of the disease and enabled the search for ...
A. Martínez-López, S. Candel, S. D. Tyrkalska   +2 more
semanticscholar   +1 more source

Silicosis and lung cancer: current perspectives [PDF]

, 2018
Takashi Sato,1 Takeshi Shimosato,2 Dennis M Klinman3 1Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan; 2Department of Interdisciplinary Genome Sciences and Cell Metabolism, Institute for ...
Klinman DM, Shimosato, Takeshi, Sato T, Shimosato T, Sato, Takashi, Klinman, Dennis M   +5 more
core   +1 more source

Silicosis: controversy in detection [PDF]

, 2014
In many countries, the work of mining, quarrying, construction of tunnels and galleries, abrasive jet cleaning and smelting continue to present significant risks of silica exposure and silicosis epidemics still occur, even in developed countries ...
Delgado García, Diemen Darwin, Delgado García, Diemen, Diemen Darwin Delgado García   +2 more
core   +3 more sources

Silicosis, tuberculosis and silica exposure among artisanal and small-scale miners: A systematic review and modelling paper

PLOS Global Public Health, 2023
An estimated 44 million artisanal and small-scale miners (ASM), largely based in developing economies, face significant occupational risks for respiratory diseases which have not been reviewed. We therefore aimed to review studies that describe silicosis
P. Howlett, Hader Mousa, Bibie Said, A. Mbuya, O. Kon, S. Mpagama, J. Feary   +6 more
semanticscholar   +1 more source

A Portugal perspective of silicosis in a poster review

, 2022
Silicosis is a well-known fibrogenic lung disease which is probably one of the most ancient occupational illness. Silicosis is a prevalent disease currently without specific treatment. So, a preventive strategy is always the best option.
Prudêncio, Cristina, Ferreira, Rui, Ferraz, Ricardo   +2 more
core   +1 more source

2-Deoxy-D-glucose ameliorates inflammation and fibrosis in a silicosis mouse model by inhibiting hypoxia-inducible factor-1α in alveolar macrophages.

Ecotoxicology and Environmental Safety, 2023
Inhaling silica causes the occupational illness silicosis, which mostly results in the gradual fibrosis of lung tissue. Previous research has demonstrated that hypoxia-inducible factor-1α (HIF-1α) and glycolysis-related genes are up-regulated in ...
Yuting Lu, M. Mu, Xiaotian RenChen, Wenyang Wang, Yingrui Zhu, Meiping Zhong, Yuerong Jiang, X. Tao   +7 more
semanticscholar   +1 more source

Analysis of Volatile Organic Compound Emissions in 3D Printing: Implications for Indoor Air Quality

Buildings
This study provides a comprehensive analysis of volatile organic compound (VOC) emissions in the context of 3D printing, a rapidly advancing technology that is transforming manufacturing processes. As the adoption of 3D printing grows, concerns regarding
Hector Garcia-Gonzalez, Teresa Lopez-Pola, Pilar Fernandez-Rubio, Pablo Fernandez-Rodriguez   +3 more
doaj   +1 more source

Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagy

Cellular & Molecular Immunology
Monocyte-derived macrophages (MoMacs) are the most important effector cells that cause pulmonary fibrosis. However, the characteristics of MoMac differentiation in silicosis and the mechanisms by which MoMacs affect the progression of pulmonary fibrosis ...
Shifeng Li, Hong Xu, Shupeng Liu, Jinkun Hou, Yueyin Han, Chen Li, Yupeng Li, Gaigai Zheng, Zhongqiu Wei, Fang Yang, Shuwei Gao, Shiyao Wang, J. Geng, H. Dai, Chen Wang   +14 more
semanticscholar   +1 more source

Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling pathways.

Ecotoxicology and Environmental Safety, 2022
Macrophages play an important role in causing silicosis eventually becoming an irreversible fibrotic disease, and there are no specific drugs for silicosis in the clinic so far.
Qiong Tang, C. Xing, M. Li, Q. Jia, C. Bo, Zhenling Zhang   +5 more
semanticscholar   +1 more source