Results 51 to 60 of about 11,574 (132)

OC-STAMP is a potential biomarker and therapeutic target for Silicosis: an exploratory investigation

Journal of Translational Medicine
Background Silicosis, a disease characterized by fibrous changes in lung tissue due to prolonged silica dust inhalation, exhibits a complex pathogenesis that remains inadequately addressed by current interventions.
Jing Wu, Bingyu Zhang, Wei Du, Yimin Shi, Chunhong Xie, Yanyan Ke, Xue Yi   +6 more
doaj   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China

BMC Pulmonary Medicine
Objectives Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among ...
Xinsong Hu, Cheng Chen, Qianqian Gao, Lang Zhou, Yan Shao, Guoli Li, Honghuan Song, Qiao Liu, Lei Han, Limei Zhu   +9 more
doaj   +1 more source

Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil [PDF]

Jornal Brasileiro de Pneumologia
Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by the inhalation of silica particles. Silica dust inhalation is associated with inflammation and induction of oxidative stress in the lungs.
Marcos César Santos de Castro, Lucas de Carvalho Costa, Kaio Cezar Rodrigues Salum, Hermano Albuquerque de Castro, Patrícia Canto Ribeiro, Walter Costa, Angela Santos Ferreira Nani, Fabiana Barzotto Kohlrausch   +7 more
doaj   +1 more source

Bilateral Spontaneous Pneumothorax in Chronic Silicosis: A Case Report

Case Reports in Pathology, 2014
Silicosis is an occupational lung disease caused by inhalation of crystalline silica. People working in occupations like sandblasting, surface drilling, tunneling, silica flour milling, ceramic making, and so forth are predisposed to develop silicosis ...
Pritinanda Mishra, Sajini Elizabeth Jacob, Debdatta Basu, Manoj Kumar Panigrahi, Vishnukanth Govindaraj   +4 more
doaj   +1 more source

Periodontal conditions and salivary microbiota are potential indicators to distinguish silicosis: an exploratory study

BMC Microbiology
Background Silicosis has always been a serious global occupational health problem. Oral microbiota plays important roles in the development of lung disease.
Shaoying Duan, Meiying Shao, Chenchen Zhang, Jialiang Zhao, Fangzhi Zhu, Nanyu Luo, Lei Lei, Ting Zhong, Tao Hu   +8 more
doaj   +1 more source

Relationship between plasma SP-A expression level and disease stage in silicosis patients

Shanghai yufang yixue
ObjectiveTo investigate the relationship between plasma surfactant protein⁃A （SP⁃A） expression level and silicosis progression， and to provide early evidence for exploring whether SP⁃A can be used as a biomarker for clinical monitoring of silicosis ...
CHEN Kengkeng, ZHANG Bizhu, PENG Yingyi, LIU Zhifang, CHEN Xiaoyan, JIN Jiachun   +5 more
doaj   +1 more source

Framework for implementing collaborative TB-silicosis activities in India: insights from an expert panel

Archives of Public Health
Tuberculosis (TB) treatment is more challenging for patients with silicosis, as it complicates the diagnosis of both diseases and increases mortality risk. Silicosis, an incurable occupational disease, confounds the diagnosis of TB and vice versa, making
Mihir P. Rupani, Pankaj Nimavat, Yogesh Patel, Harsh D. Shah, Arkaprabha Sau   +4 more
doaj   +1 more source

Activation of Sirt1 by acetate alleviates silicofibrosis: Contribution of the gut microbiota

Ecotoxicology and Environmental Safety
Silicosis is a prevalent occupational disease marked by progressive pulmonary fibrosis. Despite its significant health burden, the pathogenesis of silicosis remains unclear, and no specific therapeutic drugs are available.
Weiliang Zhang, Xuejie Qi, Mingming Han, Qiang Jia, Xixi Li, Wenhui Yin, Yanhui Wang, Heng Wu, Hua Shao, Cheng Peng, Chongyi Su, Linlin Sai   +11 more
doaj   +1 more source