Results 101 to 110 of about 447 (114)

Antieosinophilic Activity of Simendans

The Journal of Pharmacology and Experimental Therapeutics, 2007
Simendans are novel agents used in the treatment of decompensated heart failure. They sensitize troponin C to calcium and open ATP-sensitive potassium channels and have been shown to reduce cardiac myocyte apoptosis. The aim of the present study was to evaluate whether simendans reduce pulmonary eosinophilia and regulate eosinophil apoptosis ...
Hannu, Kankaanranta, Xianzhi, Zhang, Ritva, Tumelius, Minna, Ruotsalainen, Heimo, Haikala, Erkki, Nissinen, Eeva, Moilanen   +6 more
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Improved survival with simendan after experimental myocardial infarction in rats

European Journal of Pharmacology, 2001
This study compared the effects of simendan, a calcium sensitizer, with those of milrinone and enalapril on survival of rats with healed myocardial infarction. Seven days after ligation-induced myocardial infarction, the rats were randomized to control, milrinone, enalapril, or simendan groups. All compounds were administered via the drinking water for
J, Levijoki, P, Pollesello, P, Kaheinen, H, Haikala   +3 more
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Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers

Clinical Pharmacology and Therapeutics, 1994
To assess pharmacokinetics and correlation of pharmacokinetics and pharmacodynamics of simendan, a new calcium-sensitizing compound aimed at the treatment of congestive heart failure, in healthy volunteers.Simendan was administered to eight healthy subjects in seven different doses, and its concentrations in plasma and proportions of enantiomers ...
J, Lilleberg, S, Antila, M, Karlsson, M S, Nieminen, P J, Pentkäinen   +4 more
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Enantiomeric bioanalysis of simendan and levosimendan by chiral high-performance liquid chromatography

Chirality, 1996
rac-Simendan, (+/-)-(R,S)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-phenyl ] hydrazono]propanedinitrile, and the levorotatory enantiomer levosimendan, are drug candidates intended for the treatment of congestive heart failure. An enantiospecific high-performance liquid chromatographic (HPLC) method suitable for determination of the ratio of
T, Wikberg, T, Korkolainen, M, Karlsson
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Hemodynamic effects of the novel cardiotonic drug simendan: Echocardiographic assessment in healthy volunteers

Cardiovascular Drugs and Therapy, 1994
Simendan is a novel cardiotonic drug with mixed properties, including calcium sensitization. Simendan was given intravenously to eight healthy volunteers in doses from 0.1 to 10.0 mg to define its safety and dose-response effects. Its effects on myocardial function were recorded by echocardiography with simultaneous measurement of heart rate (HR) and ...
J M, Lilleberg, S, Sundberg, T, Leikola-Pelho, M S, Nieminen   +3 more
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Enatiomeric analysis of simendan by CE with β‐CD as chiral selector compared with CMPA‐HPLC

Biomedical Chromatography, 2004
AbstractThe chiral separation of simendan enantiomers using capillary electrophoresis was studied with β‐cyclodextrin (β‐CD) as chiral selector. The influences of the concentration and pH of borate buffer solution, β‐CD concentration and methanol content in the background electrolyte were investigated.
Famei, Li, Dandan, Zhang, Xiumei, Lu, Yuling, Wang, Zhili, Xiong   +4 more
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Inotropic effect of simendan in combined hypoxia, hyperkalaemia and acidosis

Pharmacological Research, 1992
Lajos Mester, Julius Gy. Papp
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The effects of a new calcium sensitizer, Simendan, on intra-cellular protein phosphorylation

Journal of Molecular and Cellular Cardiology, 1992
István Édes, Gyula J Papp, Miklós Csanády   +2 more
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Studies on calcium-dependent binding of simendan to troponin complex and troponin C

Journal of Molecular and Cellular Cardiology, 1992
Martti Ovaska, Helmo Halkala, Kenneth Lundström, Taplo Korkolainen, Jyrki Taskinen, Inge-Britt Lindén   +5 more
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Inhibition by simendan (OR-1259) of collagen-and Ca2+-ionophore induced aggregation of human platelets

Pharmacological Research, 1992
Janos Pataricza, Julius Gy. Papp
openaire   +1 more source