Results 101 to 110 of about 469 (114)
Cardiovascular Drugs and Therapy, 1994 Simendan is a novel cardiotonic drug with mixed properties, including calcium sensitization. Simendan was given intravenously to eight healthy volunteers in doses from 0.1 to 10.0 mg to define its safety and dose-response effects. Its effects on myocardial function were recorded by echocardiography with simultaneous measurement of heart rate (HR) and ...
J M, Lilleberg +3 more
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Antieosinophilic Activity of Simendans
The Journal of Pharmacology and Experimental Therapeutics, 2007 Simendans are novel agents used in the treatment of decompensated heart failure. They sensitize troponin C to calcium and open ATP-sensitive potassium channels and have been shown to reduce cardiac myocyte apoptosis. The aim of the present study was to evaluate whether simendans reduce pulmonary eosinophilia and regulate eosinophil apoptosis ...
Hannu, Kankaanranta +6 more
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Improved survival with simendan after experimental myocardial infarction in rats
European Journal of Pharmacology, 2001 This study compared the effects of simendan, a calcium sensitizer, with those of milrinone and enalapril on survival of rats with healed myocardial infarction. Seven days after ligation-induced myocardial infarction, the rats were randomized to control, milrinone, enalapril, or simendan groups. All compounds were administered via the drinking water for
J, Levijoki +3 more
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Enatiomeric analysis of simendan by CE with β‐CD as chiral selector compared with CMPA‐HPLC
Biomedical Chromatography, 2004 AbstractThe chiral separation of simendan enantiomers using capillary electrophoresis was studied with β‐cyclodextrin (β‐CD) as chiral selector. The influences of the concentration and pH of borate buffer solution, β‐CD concentration and methanol content in the background electrolyte were investigated.
Famei, Li +4 more
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Inotropic effect of simendan in combined hypoxia, hyperkalaemia and acidosis
Pharmacological Research, 1992 Lajos Mester, Julius Gy. Papp
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The effects of a new calcium sensitizer, Simendan, on intra-cellular protein phosphorylation
Journal of Molecular and Cellular Cardiology, 1992 István Édes +2 more
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Studies on calcium-dependent binding of simendan to troponin complex and troponin C
Journal of Molecular and Cellular Cardiology, 1992 Martti Ovaska +5 more
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