Results 71 to 80 of about 27,759 (187)

The Importance of Pediatric Nonhuman Primate Models in Translational HIV Research

Journal of Medical Primatology, Volume 55, Issue 2, April 2026.
ABSTRACT Despite extraordinary global progress in the prevention and treatment of HIV, pediatric HIV remains a significant and under‐addressed component of the global epidemic. In her keynote presentation at the Pediatric Nonhuman Primate (NHP) Workshop in October 2024, Dr.
Ann Chahroudi
wiley   +1 more source

Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses

Journal of Virology
Human immunodeficiency virus type 1 (HIV-1) originated following cross-species transmission of simian immunodeficiency virus (SIV) infecting chimpanzees (SIVcpz).
Angelina M. Baldino, Mitchell J. Mumby, Cassandra R. Edgar, Abayomi S. Olabode, Art F. Y. Poon, Jimmy D. Dikeakos   +5 more
doaj   +1 more source

Galectin-3, galectin-9, and interleukin- 18, monocyte activation and turnover and simian immunodeficiency virus-associated 2 cardiac pathology or encephalitis: A narrative review

Indian Journal of Allergy Asthma and Immunology
In the context of simian immunodeficiency virus (SIV) infection, this editorial commentary minireview addresses the roles of galectin-3, galectin-9, and interleukin-18 in monocyte activation and turnover.
Hinpetch Daungsupawong, Viroj Wiwanitkit
doaj   +1 more source

The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques

Toxins, 2015
Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation
Rui-Rui Wang, Ka-Yee Au, Hong-Yi Zheng, Liang-Min Gao, Xuan Zhang, Rong-Hua Luo, Sue Ka-Yee Law, Amanda Nga-Sze Mak, Kam-Bo Wong, Ming-Xu Zhang, Wei Pang, Gao-Hong Zhang, Pang-Chui Shaw, Yong-Tang Zheng   +13 more
doaj   +1 more source

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

Nature Communications, 2017
HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3.
Santiago Manrique, Daniel Sauter, Florian A. Horenkamp, Sebastian Lülf, Hangxing Yu, Dominik Hotter, Kanchan Anand, Frank Kirchhoff, Matthias Geyer   +8 more
doaj   +1 more source

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

Genome Medicine, 2018
B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe a bioinformatic pipeline, BALDR (BCR Assignment of Lineage using D e novo Reconstruction) that accurately reconstructs the ...
Amit A. Upadhyay, Robert C. Kauffman, Amber N. Wolabaugh, Alice Cho, Nirav B. Patel, Samantha M. Reiss, Colin Havenar-Daughton, Reem A. Dawoud, Gregory K. Tharp, Iñaki Sanz, Bali Pulendran, Shane Crotty, F. Eun-Hyung Lee, Jens Wrammert, Steven E. Bosinger   +14 more
doaj   +1 more source

Quantification of Viral RNA and DNA Positive Cells in Tissues From Simian Immunodeficiency Virus/Simian Human Immunodeficiency Virus Infected Controller and Progressor Rhesus Macaques

Frontiers in Microbiology, 2019
Eradication of human immunodeficiency virus 1 (HIV-1) from an infected individual cannot be achieved using current antiretroviral therapy (ART) regimens.
Bapi Pahar, Dot Kuebler, Terri Rasmussen, Xiaolei Wang, Sudesh K. Srivastav, Arpita Das, Ronald S. Veazey   +6 more
doaj   +1 more source

Understanding the Process of Envelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses

Viruses, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
José L. Affranchino, Silvia A. González   +1 more
doaj   +1 more source

Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

Pathogens and Immunity, 2016
Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV.
Said A. Hassounah, Thibault Mesplède, Mark A. Wainberg   +2 more
doaj   +1 more source

Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIV_smm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization

mBio, 2019
As a consequence of their independent evolutionary origins in apes and Old World monkeys, human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses of the SIVsmm/mac lineage express phylogenetically and antigenically distinct ...
Benjamin von Bredow, Raiees Andrabi, Michael Grunst, Andres G. Grandea, Khoa Le, Ge Song, Zachary T. Berndsen, Katelyn Porter, Jesper Pallesen, Andrew B. Ward, Dennis R. Burton, David T. Evans   +11 more
doaj   +1 more source