Results 51 to 60 of about 27,759 (187)

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Electrostatic potential of human immunodeficiency virus type 2 and rhesus macaque simian immunodeficiency virus capsid proteins

Frontiers in Microbiology, 2012
Human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency virus isolated from a macaque monkey (SIVmac) are assumed to have originated from simian immunodeficiency virus isolated from sooty mangabey (SIVsm).
Katarzyna eBozek, Emi E. Nakayama, Ken eKono, Tatsuo eShioda   +3 more
doaj   +1 more source

T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ...
Barbara L. Shacklett, Ramatoulaye H. Ouattara, April L. Ferre   +2 more
wiley   +1 more source

Novel Multiplexed HIV/Simian Immunodeficiency Virus Antibody Detection Assay

Emerging Infectious Diseases, 2011
Like most emerging infectious disease viruses, HIV is also of zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collected ...
Steve Ahuka-Mundeke, Ahidjo Ayouba, Placide Mbala-Kingebeni, Florian Liegeois, Amandine Esteban, Octavie Lunguya-Metila, Didace Demba, Guy Bilulu, Valentin Mbenzo-Abokome, Bila-Isia Inogwabini, Jean-Jacques Muyembe-Tamfum, Eric Delaporte, Martine Peeters   +12 more
doaj   +1 more source

Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV. [PDF]

PLoS ONE, 2014
RT-SHIV is a chimera of simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT)-encoding region of human immunodeficiency virus type 1 (HIV-1) within the backbone of SIVmac239.
Debra A Wadford, Robert C Kauffman, Jesse D Deere, Scott T Aoki, Richard A Stanton, Joanne Higgins, Koen K A Van Rompay, Andradi Villalobos, James H Nettles, Raymond F Schinazi, Niels C Pedersen, Thomas W North   +11 more
doaj   +1 more source

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias, Claudia C. Stroupe, Thatiane Russo, Thomas J. Hope   +3 more
wiley   +1 more source

Impact of Recombinant VSV-HIV Prime, DNA-Boost Vaccine Candidates on Immunogenicity and Viremia on SHIV-Infected Rhesus Macaques

Vaccines
Currently, no effective vaccine to prevent human immunodeficiency virus (HIV) infection is available, and various platforms are being examined. The vesicular stomatitis virus (VSV) vaccine vehicle can induce robust humoral and cell-mediated immune ...
Alice Berger, Jannie Pedersen, Monika M. Kowatsch, Florine Scholte, Marc-Alexandre Lafrance, Hiva Azizi, Yue Li, Alejandro Gomez, Matthew Wade, Hugues Fausther-Bovendo, Marc-Antoine de La Vega, Joseph Jelinski, George Babuadze, Marie-Edith Nepveu-Traversy, Claude Lamarre, Trina Racine, Chil-Yong Kang, Bruno Gaillet, Alain Garnier, Rénald Gilbert, Amine Kamen, Xiao-Jian Yao, Keith R. Fowke, Eric Arts, Gary Kobinger   +24 more
doaj   +1 more source

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

Viruses, 2015
The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1
Oliver T. Fackler
doaj   +1 more source

Pediatric NIH Workshop: Session III—Specialties and Complexities of Juvenile NHP Models for HIV Prevention Research

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT Nonhuman primates (NHPs) have emerged as an indispensable model for studying HIV pathogenesis, vaccines, and therapies. The development of chimeric Simian/Human immunodeficiency viruses (SHIVs) has been constructed by inserting HIV‐1 Env into the SIV (usually SIVmac239) backbone, and these have proved essential for evaluating HIV neutralizing ...
A. J. Hessell, M.‐C. Gauduin, F. Villinger   +2 more
wiley   +1 more source

Antibiotic Minocycline Prevents Respiratory Syncytial Virus Infection

Viruses, 2019
Treatment drugs, besides their specific activity, often have multiple effects on the body. The undesired effect of the drug may be repurposed as therapeutics, saving significant investigative time and effort.
Swapnil S. Bawage, Pooja M. Tiwari, Shreekumar Pillai, Vida A. Dennis, Shree R. Singh   +4 more
doaj   +1 more source