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Fibrosarcoma on the leg of an adult rhesus macaque (Macaca mulatta)
Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.Abstract
This case describes a fibrosarcoma on the left upper leg of an adult female rhesus macaque. The patient was initially presented with a defined swelling at the caudolateral side of the upper leg. Medially from the growth, a swollen circular wound had formed with a fistula leading in the direction of the mass.Merel Wegman, Nadiah M. H. A. van Eijk, Jaco Bakker, Judith M. A. van den Brand, Jan A. M. Langermans +4 morewiley +1 more sourceIncreased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity
Pathogens and Immunity
Background: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV ...Junsuke Nohara, Tyler Evangelous, Madison Berry, Whitney Beck, Sarah Mudrak, Shalini Jha, R. Keith Reeves, Kevin J. Wiehe, Justin Pollara, Georgia Tomaras, Todd Bradley, Guido Ferrari +11 moredoaj +1 more sourceMacaque models of human infectious disease. [PDF]
, 2008 Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions.Abe, Adams, Ahmed, Ajariyakhajorn, Albrecht, Allen, Apetrei, Apetrei, Arroyo, Bai, Bannantine, Barker, Barnett, Barouch, Baskerville, Baskin, Baze, Bennett, Blanchard, Blaney, Bons, Boonjakuakul, Breitschwerdt, Brooks, Brown, Bruce, Campos, Capone, Capone, Carbone, Carlson, Carlson, CARVALHO, Chan, Chattopadhyay, Chen, Chen, Chenine, Choi, Chomel, Choo, Chopra, Christe, Coalson, Coban, Cohen, Cohen, Contreras, Courgnaud, Custer, Cypess, Daddario-DiCaprio, Daddario-Dicaprio, Dalgard, Daniel, de Swart, Dezzutti, Di Giulio, Dittmer, Doi, Donnelly, Dubois, Dubois, Dutta, Earl, Edghill-Smith, Edghill-Smith, Ekanayake, Engel, Escalante, Espana, Farber, Feichtinger, Fisher-Hoch, Fisher-Hoch, Fitzgeorge, Fogg, Foley, Foucault, Fritz, Frolova, Gajdusek, Gallinella, Gao, Gardner, Gardner, Gardner, Gaynor, Geisbert, Geisbert, Geisbert, Geisbert, Gheit, Gibbs, Giddens, Goldstein, Gonder, Good, Gormus, Gormus, Goverdhan, Graczyk, Graff, Gray, Green, Guirakhoo, Haagmans, Haase, Habis, Hambleton, Hansen, Hawley, Heise, Heraud, Herzog, Hessell, Hicks, Higashi, Hirano, Hirsch, Hooper, Hotez, Hubbert, Hull, Hunsmann, Hutin, Ilyinskii, Inoue, Ivanoff, Jahrling, Ji, Johnson, Johnson, Jones-Engel, Jones-Engel, Kao, Kawai, Kawai, Kennedy, Kenyon, Kestler, Kinsey, Kishimoto, Klingstrom, Klumpp, Kobasa, Kobune, Kodama, Kornegay, Kuiken, Kuiken, Kunz, Kutok, Kwang, Lackner, Lake-Bakaar, Lasm zas, Le Bras, Leong, Leroy, Letvin, Letvin, Letvin, Levine, Li, Li, Lichtenwalner, Lindsley, Line, Ling, Linial, Lockridge, Lodmell, Lowenstine, Lukashevich, Lukashevich, Lusso, Maddison, Mankowski, Mansfield, Mansfield, Marra, Marthas, Marthas, Marx, Mason, Masters, Matz-Rensing, Maul, McArthur-Vaughan, McMichael, McNeely, McShane, Meisenhelder, Mense, Miller, Miyoshi, Moghaddam, Monath, Mon , Mooser, Morris, Morton, Mulder, Murphey-Corb, Murphy, Murphy, Myint, Nagle, NI, North, Novembre, O'Rourke, O'Sullivan, O'Sullivan, Olson, Ostrow, Ostrow, Oswald, Pachner, Pachner, Pachner, Pahar, Palmer, Palmer, Patton, Patton, Paul, Peiris, Percy, Perelygina, Permar, Persson, Peters, Peters, Petschow, Philipp, Philipp, Phipps, Pialoux, Pletnev, Polack, Pung, Puri, Raengsakulrach, Raether, Ratterree, Reed, Reimann, Reindel, Renne, Rhesus Macaque Genome Sequencing and Analysis Cons, Rimmelzwaan, Rimmelzwaan, Rivailler, Rockx, Rodas, Rue, Ruff, Russell, Saadat, Sale, Samuel, Sato, Schou, Schou, Schricker, Schultz, Sequar, Sestak, Shah, Shen, Shevtsova, Shuto, Simoes, Smit-McBride, Smith, Smith, Soike, Solnick, Solnick, Spencer, Stittelaar, Stittelaar, Stittelaar, Stokes, Subekti, Suss, Tanaka, Tanghe, Taylor, Taylor, Tribe, Tulis, Turell, Uberla, van den Hoogen, van Gorder, Van Heuverswyn, Van Rompay, Van Voorhis, Vasconcelos, Vasconcelos, Veazey, Voevodin, Vogel, Walsh, WALSH, Weinmann, Weiss, Wells, Wengelnik, Wenner, Westerman, White, Whitney, Williamson, Williamson, Willy, Wobus, Wolf, Wolfe, Wood, Wright, Wyatt, Xu, Yalcin, Zaucha, Zhou, Zuckerman, Zumpe +330 morecore +1 more sourceSimian immunodeficiency virus DNA vaccine trial in macaques [PDF]
Journal of Virology, 1995 An experimental vaccine consisting of five DNA plasmids expressing different combinations and forms of simian immunodeficiency virus-macaque (SIVmac) proteins has been evaluated for the ability to protect against a highly pathogenic uncloned SIVmac251 challenge. One vaccine plasmid encoded nonreplicating SIVmac239 virus particles.Lu, Shan, Arthos, James, Montefiori, David C., Yasutomi, Yasuhiro, Manson, Kelledy, Mustafa, Farah, Johnson, Eric, Santoro, Joseph C., Wissink, J., Mullins, James I., Haynes, Joel R., Letvin, Norman L., Wyand, Michael, Robinson, Harriet L. +13 moreopenaire +5 more sourcesAge‐Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV‐Infected Macaques
Aging Cell, Volume 24, Issue 12, December 2025.Virally suppressed older people with HIV have larger peripheral blood CD4+ T‐cell reservoirs than younger individuals, correlating with CD4+ and CD8+ T‐cell activation. Similar results were seen in SIV‐infected, ART‐treated aged rhesus macaques. ABSTRACT
With the advancement of combination antiretroviral therapy (ART), over 50% of people with HIV (PWH) Arpan Acharya, Debapriya Sutar, Mahesh Mohan, Varan Govind, Francois Villinger, Suresh Pallikkuth, Siddappa N. Byrareddy +6 morewiley +1 more sourceReplicating Adenovirus-Simian Immunodeficiency Virus (SIV) Vectors Efficiently Prime SIV-Specific Systemic and Mucosal Immune Responses by Targeting Myeloid Dendritic Cells and Persisting in Rectal Macrophages, Regardless of Immunization Route
Clinical and Vaccine Immunology, 2012 Although priming with replicating adenovirus type 5 host range mutant (Ad5hr)-human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) recombinants, followed by HIV/SIV envelope boosting, has proven highly immunogenic, resulting in ...L. Patterson, S. Kuate, M. Daltabuit-Test, Qingsheng Li, Peng Xiao, L. Patterson, Jean, S. Kuate, M. Daltabuit-Test, Qingsheng Li, Peng Xiao, K. McKinnon, J. Dipasquale, A. Cristillo, D. Venzon, A. Haase, Robert-Guroff, Marjorie, Replicating Adenovirus, Simian Immunodeficiency +19 moresemanticscholar +1 more sourceIdentification and Verification of Immune Metabolism–Related Biomarkers and Immune Infiltration Landscape for Pediatric Opsoclonus Myoclonus Ataxia Syndrome in Neuroblastoma
CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.Based on the GEO database and GeneCards database, 1785 immune metabolism genes, 1879 DEGs, and 1560 module genes were screened out. After taking the intersection, 162 differential immune metabolic–related genes were obtained. Four diagnostic biomarker genes, TRAF3IP2, RIPK1, KEAP1, and DPP4, were screened out through three machine learning algorithms ...Minglei Li, Jinlei Liwiley +1 more sourceVariation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV. [PDF]
PLoS ONE, 2014 RT-SHIV is a chimera of simian immunodeficiency virus (SIV) containing the reverse transcriptase (RT)-encoding region of human immunodeficiency virus type 1 (HIV-1) within the backbone of SIVmac239.Debra A Wadford, Robert C Kauffman, Jesse D Deere, Scott T Aoki, Richard A Stanton, Joanne Higgins, Koen K A Van Rompay, Andradi Villalobos, James H Nettles, Raymond F Schinazi, Niels C Pedersen, Thomas W North +11 moredoaj +1 more sourceOrganoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han +4 morewiley +1 more source
