Results 81 to 90 of about 1,779,341 (295)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Unified Probabilistic and Similarity-Based Position Estimation from Radio Observations

Sensors
We propose a modeling approach for position estimation based on the observed radio propagation in an environment. The approach is purely similarity-based and therefore free of explicit physical assumptions.
Max Werner, Markus Bullmann, Toni Fetzer, Frank Deinzer   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Emergence of Similar Personalities in Similar Occupations

Journal of Organizational Behavior
ABSTRACTPersonality research suggests that individuals tend to develop more homogeneous—or similar—personalities within, rather than between, occupations due to attraction and selection, attrition, and socialization effects. We expand this perspective using a distance‐based methodological approach that relates similarities between combinations of ...
Claudia Rossetti, Torsten Biemann, Katja Dlouhy   +2 more
openaire   +2 more sources

On the similarity of tensors

Linear Algebra and its Applications, 2014
Let $\mathbb{P}_n$ be the set of all matrices which have the same zero patterns with some permutation matrix of order $n$. In this paper, we prove the following result: Let $\mathbb{I}$ be the unit tensor of order $m\ge3$ and dimension $n\ge2$. Suppose that $P$ and $Q$ are two matrices with $P\mathbb{I}Q=\mathbb{I}$, then $P,Q\in \mathbb{P}_n$.
Pingzhi Yuan, Lihua You
openaire   +3 more sources

Similarity-clustering of unmapped reads.

, 2016
Black semi-filled phylogenic background denotes male samples. Euclidean distance-based clustering of strains on basis of the percentage between-strain read-pair sequence similarity, with a minimal sequence similarity of two non-overlapping blocks of 34bp.
Robin H. van der Weide (2922057), Pim Toonen (713092), Joep de Ligt (2922051), Roel Hermsen (713091), Edwin Cuppen (9902), Marieke Simonis (86953)   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Research on Technique of Extracting Knowledge from Maintenance Experiences Based on Conceptual Graph

MATEC Web of Conferences, 2015
Experience knowledge is extremely important in maintenance domain. However, it is difficult to express and extract this kind of knowledge. Conceptual Graph is a new and powerful visual knowledge representation method.
Liu Yanbin, Qian Yanling, Wang Long, Xu Tengfei   +3 more
doaj   +1 more source