Results 71 to 80 of about 416,391 (281)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A Demosaicking Algorithm with Adaptive Inter-Channel Correlation

open access: yesImage Processing On Line, 2015
Most common cameras use a CCD sensor device measuring a single color per pixel. Demosaicking is the interpolation process by which one can infer a full color image from such a matrix of values, thus interpolating the two missing components per pixel ...
Joan Duran, Antoni Buades
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Fractal nematic colloids

open access: yesNature Communications, 2017
Topological defects in nematic liquid crystals can be controlled upon external stimuli for designing novel photonic materials. Here, Hashemiet al. show geometry-induced formation of fractal defects in nematic fluids with the fractal self-similarity more ...
S. M. Hashemi   +5 more
doaj   +1 more source

Cortical gradient of a human functional similarity network captured by the geometry of cytoarchitectonic organization

open access: yesCommunications Biology, 2022
Analysis of functional MRI data from the Human Connectome Project reveals the presence of a cortical gradient, which reflects functional topology and links the macroscale functional landscape with mesoscale laminar differentiation principles.
Yao Meng   +6 more
doaj   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu   +14 more
wiley   +1 more source

From Fractal Geometry to Statistical Fractal

open access: yesRecoletos Multidisciplinary Research Journal, 2013
The development from fractal geometry to fractal statistics was established in this paper. Interesting features such as self similarity, scale invariance, and the spacefilling property of objects (fractal dimension) of fractal geometry provided an ...
Roberto N. Padua, Mark S. Borres
doaj   +1 more source

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