Results 151 to 160 of about 9,169,557 (320)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

StructSim: Meta-Structure-Based Similarity Measure in Heterogeneous Information Networks

Applied Sciences
Similarity measures in heterogeneous information networks (HINs) have become increasingly important in recent years. Most measures in such networks are based on the meta path, a relation sequence connecting object types. However, in real-world scenarios,
Yuyan Zheng, Jianhua Qu, Jiajia Yang
doaj   +1 more source

An Efficient Parallelized Ontology Network-Based Semantic Similarity Measure for Big Biomedical Document Clustering. [PDF]

Comput Math Methods Med, 2021
Li M, Chen T, Ryu KH, Jin CH.
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A REVIEW OF THE MOST COMMON PARTITION ALGORITHMS IN CLUSTER ANALYSIS: A COMPARATIVE STUDY UNA REVISIÓN DE LOS ALGORITMOS DE PARTICIÓN MÁS COMUNES EN EL ANÁLISIS DE CONGLOMERADOS: UN ESTUDIO COMPARATIVO

Revista Colombiana de Estadística, 2010
This study is oriented to compare several partition methods in the context of cluster analysis, which are also called non hierarchical methods. In this work, a simulation study is performed to compare the results obtained from the implementation of the ...
Leiva-Valdebenito Susana A., Torres-Avilés Francisco J.   +1 more
doaj  

A New in Silico Antibody Similarity Measure Both Identifies Large Sets of Epitope Binders with Distinct CDRs and Accurately Predicts Off-Target Reactivity. [PDF]

Int J Mol Sci, 2022
Musnier A, Bourquard T, Vallet A, Mathias L, Bruneau G, Ayoub MA, Travert O, Corde Y, Gallay N, Boulo T, Cortes S, Watier H, Crépieux P, Reiter E, Poupon A.   +14 more
europepmc   +1 more source

OCRM: Optimal Cost Region Matching Similarity Measure for Region Based Image Retrieval

, 2014
Gnaneswara Rao Nitta, T. Sravani, V. Vijaya Kumar   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Una revisión de los algoritmos de partición más comunes en el análisis de conglomerados: un estudio comparativo

Revista Colombiana de Estadística, 2010
Este estudio está enfocado en comparar diversos métodos de partición del análisis de conglomerados, usualmente conocidos como métodos no jerárquicos.
SUSANA A. LEIVA-VALDEBENITO, FRANCISCO J. TORRES-AVILÉS   +1 more
doaj  

Multicriteria group decision making via generalized trapezoidal intuitionistic fuzzy number-based novel similarity measure and its application to diverse COVID-19 scenarios. [PDF]

Artif Intell Rev, 2023
Dutta P, Borah G.
europepmc   +1 more source