Results 141 to 150 of about 1,583,595 (288)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A pairwise functional connectivity similarity measure method based on few-shot learning for early MCI detection. [PDF]

Front Neurosci, 2022
Zhang X, Shams SP, Yu H, Wang Z, Zhang Q.   +4 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A theoretical development of improved cosine similarity measure for interval valued intuitionistic fuzzy sets and its applications. [PDF]

J Ambient Intell Humaniz Comput, 2022
Rathnasabapathy P, Palanisami D.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Boolean logic algebra driven similarity measure for text based applications. [PDF]

PeerJ Comput Sci, 2021
Abdalla HI, Amer AA.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A REVIEW OF THE MOST COMMON PARTITION ALGORITHMS IN CLUSTER ANALYSIS: A COMPARATIVE STUDY UNA REVISIÓN DE LOS ALGORITMOS DE PARTICIÓN MÁS COMUNES EN EL ANÁLISIS DE CONGLOMERADOS: UN ESTUDIO COMPARATIVO

Revista Colombiana de Estadística, 2010
This study is oriented to compare several partition methods in the context of cluster analysis, which are also called non hierarchical methods. In this work, a simulation study is performed to compare the results obtained from the implementation of the ...
Leiva-Valdebenito Susana A., Torres-Avilés Francisco J.   +1 more
doaj  

A Similarity Measure for Linking CoinJoin Output Spenders

Journal of Cybersecurity and Privacy
This paper introduces a novel similarity measure to link transactions which spend outputs of CoinJoin transactions, CoinJoin Spending Transactions (CSTs), by analyzing their on-chain properties, addressing the challenge of preserving user privacy in ...
Michael Herbert Ziegler, Mariusz Nowostawski, Basel Katt   +2 more
doaj   +1 more source

MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra. [PDF]

J Cheminform, 2021
Huber F, van der Burg S, van der Hooft JJJ, Ridder L.   +3 more
europepmc   +1 more source