Results 151 to 160 of about 1,583,595 (288)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Correction: Biological Characteristics of Cell Similarity Measure
Advanced Intelligent Systems, 2022 Qingqing Hu +6 more
doaj +1 more source
Revista Colombiana de Estadística, 2010 Este estudio está enfocado en comparar diversos métodos de partición del análisis de conglomerados, usualmente conocidos como métodos no jerárquicos.
SUSANA A. LEIVA-VALDEBENITO +1 more
doaj
An Efficient Parallelized Ontology Network-Based Semantic Similarity Measure for Big Biomedical Document Clustering. [PDF]
Comput Math Methods Med, 2021 Li M, Chen T, Ryu KH, Jin CH.
europepmc +1 more source
Random Markov-self-similar measures
Stochastic Processes and their Applications, 2002 Self-similar fractal sets in the Euclidean space are usually constructed by applying iteratively a fixed finite family of contractive mappings to a given initial set. Random self-similar sets are obtained if the contractive mappings are chosen randomly and independently at each step, following a prescribed distribution.
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source