Results 161 to 170 of about 1,328,289 (291)
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Advanced Science, EarlyView.xx xx. ABSTRACT Fabric‐based wearable electronics are gaining increasing attention owing to their flexibility, breathability, biocompatibility, and seamless integration into clothing. However, most existing studies rely primarily on metallic or carbon‐based conductive materials.
Thirumalaisamy Suryaprabha +6 more
wiley +1 more source
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Advanced Science, EarlyView.CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng +12 more
wiley +1 more source
Nickel‐Catalyzed Twofold Conjunctive Coupling via Philicity‐Alternating Radical Relay
Advanced Science, EarlyView.Herein, we disclose a nickel‐catalyzed twofold conjunctive coupling that enables a four‐component assembly involving an activated alkene, a 1,3‐enyne, and both alkyl and aryl halides. Multiple C–C bonds are selectively constructed through a philicity‐alternating radical relay and the selective radical capture by the nickel catalyst.
Ji Hwan Jeon +7 more
wiley +1 more source
Multimodal Simon Effect: A Multimodal Extension of the Diffusion Model for Conflict Tasks. [PDF]
Front Hum Neurosci, 2018 Mahani MN +3 more
europepmc +1 more source
Advanced Science, EarlyView.A photothermal‐responsive engineered platelet‐rich plasma hydrogel (CNB‐ePRP) incorporated with thrombin‐functionalized composite nanobottle was developed, which enables in situ PRP activation, on‐demand growth factor release, multifunctionality, and personalized antimicrobial loading for treatment of diabetic wounds. The CNB‐ePRP hydrogel demonstrated
Wen‐Qiang Qu +8 more
wiley +1 more source
Somatotopic representation of location: evidence from the Simon effect. [PDF]
J Exp Psychol Hum Percept Perform, 2014 Medina J +3 more
europepmc +1 more source
Advanced Science, EarlyView.An ultrasoft yet tough organohydrogel (AQGL) with 5800% stretchability and 14.3 kPa modulus is developed via a novel molecular chain lubrication strategy. It features optical transparency, drying/freezing (−40°C) tolerance, antibacterial activity, conductivity, self‐healing, and adhesiveness.
Si Wang +9 more
wiley +1 more source
The Multimodal Go-Nogo Simon Effect: Signifying the Relevance of Stimulus Features in the Go-Nogo Simon Paradigm Impacts Event Representations and Task Performance. [PDF]
Front Psychol, 2018 Dolk T, Liepelt R.
europepmc +1 more source