Results 91 to 100 of about 25,178,865 (330)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Torsion units in integral group rings of Janko simple groups

, 2010
Using the Luthar--Passi method, we investigate the classical Zassenhaus conjecture for the normalized unit group of integral group rings of Janko sporadic simple groups. As a consequence, we obtain that the Gruenberg-Kegel graph of the Janko groups $J_1$,
Bovdi, V. A., Jespers, E., Konovalov, A. B.   +2 more
core   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Simplicity of skew group rings of abelian groups

, 2012
Given a group G, a (unital) ring A and a group homomorphism $\sigma : G \to \Aut(A)$, one can construct the skew group ring $A \rtimes_{\sigma} G$. We show that a skew group ring $A \rtimes_{\sigma} G$, of an abelian group G, is simple if and only if its
Öinert, Johan
core   +1 more source

A characterization of Janko’s simple group [PDF]

Proceedings of the American Mathematical Society, 1968
If G is a finite group, we say that a series of subgroups G = Go > G > * > Gn= 1 is a maximal series of length n of G if Gi is a maximal subgroup of Gi1, 1 _ i < n. A subgroup H of G is called mth maximal in G if there exists at least one maximal series H= Gm< Gm.,-<
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

$G$-permutable Subgroups in $\operatorname{PSL}_2(q)$ and Hereditarily $G$-permutable Subgroups in $\operatorname{PSU}_3(q)$

Известия Иркутского государственного университета: Серия "Математика"
The concept of $X$-permutable subgroup, introduced by A. N. Skiba, generalizes the classical concept of a permutable subgroup. Many classes of finite groups have been characterized in terms of $X$-permutable subgroups.
A. A. Galt, V. N. Tyutyanov
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Demonstration of negative group delays in a simple electronic circuit

, 2002
We present a simple electronic circuit which produces negative group delays for base-band pulses. When a band-limited pulse is applied as the input, a forwarded pulse appears at the output.
Kitano, M., Nakanishi, T., Sugiyama, K.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source