Results 71 to 80 of about 1,692,668 (268)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On Tensor Products of Simple Modules for Simple Groups [PDF]
Algebras and Representation Theory, 2011 In an attempt to get some information on the multiplicative structure of the Green ring we study algebraic modules for simple groups, and associated groups such as quasisimple and almost-simple groups. We prove that, for almost all groups of Lie type in defining characteristic, the natural module is non-algebraic.
openaire +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Non-simple localizations of finite simple groups
Journal of Algebra, 2006 10 ...
Rodríguez, José L. +2 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Reducing Broad-Spectrum Antibiotic Treatment of Simple Group A Streptococcal Infections to Reduce Harm to the Microbiome. [PDF]
Cureus, 2021 Sumibcay TJ +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
DERANGEMENTS IN SIMPLE AND PRIMITIVE GROUPS [PDF]
, 2003 To appear in Proceedings of Durham Conference on Groups, Geometry, and Combinatorics (2001)
Fulman, Jason, Guralnick, Robert
openaire +2 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Simple Group Choice: A minimal-information multi-criteria group decision aiding approach
Operations Research PerspectivesIn many real group decision-making problems, decisions must be made with limited data and busy Decision Makers (DMs). In such settings, asking for detailed scores or trade-off weights can be unrealistic and can obscure, rather than clarify, how a ...
River Huang
doaj +1 more source