Results 101 to 110 of about 6,532,487 (336)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Embedding rank one simple groups into rank one simple Riesz groups [PDF]
Glasgow Mathematical Journal, 2002 We give a method for embedding a large family of partially ordered simple groups of rank one into simple Riesz groups of rank one. In particular, we answer in the affirmative a question of Wehrung, by constructing a torsion-free, simple Riesz group G of rank one containing an interval D\varsubsetneqq G^+ such that 2D=G^+.
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Quantitative characterization of finite simple groups: a complement [PDF]
International Journal of Group TheoryIn this paper, we summarize the research on the characterization of finite simple groups and the study of finite groups based on their ``set of element orders" and ``two orders" (the order of the group and the set of element orders). We also discuss some
Wujie Shi
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
, 2020 The distinguishing number $D( )$ of a graph $ $ is the least size of a partition of the vertices of $ $ such that no non-trivial automorphism of $ $ preserves this partition. We show that if the automorphism group of a graph $ $ is simple, than $D( )=2$. This is obtained by establishing the distinguishing number for all possible actions of simple
Grech, Mariusz, Kisielewicz, Andrzej
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
FINITELY GENERATED INFINITE SIMPLE GROUPS OF INFINITE SQUARE WIDTH AND VANISHING STABLE COMMUTATOR LENGTH [PDF]
, 2010 Alexey Muranov
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