Results 121 to 130 of about 6,369,178 (336)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Factorisations of characteristically simple groups

open access: yesJournal of Algebra, 2002
A group factorization is a pair \((G,\{A,B\})\) where \(G\) is a group and \(A\), \(B\) are subgroups such that \(AB=G\). The factorization is nontrivial if \(A\neq G\neq B\). Such a factorization is a full factorization if \(|G|\), \(|A|\) and \(|B|\) are divisible by the same primes. In [J. Algebra 204, No.
Csaba Schneider, Cheryl E. Praeger
openaire   +2 more sources

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

Representations of extensions of simple groups

open access: yesArchiv der Mathematik
Abstract Feit and Tits (1978) proved that a nontrivial projective representation of minimal dimension of a finite extension of a finite nonabelian simple group G factors through a projective representation of G, except for some groups of Lie type in characteristic 2; the exact exceptions for G were determined by Kleidman and Liebeck (1989 ...
Scott Harper, Martin W. Liebeck
openaire   +5 more sources

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