Results 81 to 90 of about 9,494,908 (294)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Admissible groups, symmetric factor sets, and simple algebras
International Journal of Mathematics and Mathematical Sciences, 1984 Let K be a field of characteristic zero and suppose that D is a K-division algebra; i.e. a finite dimensional division algebra over K with center K. In Mollin [1] we proved that if K contains no non-trivial odd order roots of unity, then every finite odd
R. A. Mollin
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Generation problems for finite groups [PDF]
, 2012 It can be deduced from the Burnside Basis Theorem that if G is a finite p-group with d(G)=r then given any generating set A for G there exists a subset of A of size r that generates G. We have denoted this property B.
McDougall-Bagnall, Jonathan M.
core +2 more sources
On Tensor Products of Simple Modules for Simple Groups [PDF]
Algebras and Representation Theory, 2011 In an attempt to get some information on the multiplicative structure of the Green ring we study algebraic modules for simple groups, and associated groups such as quasisimple and almost-simple groups. We prove that, for almost all groups of Lie type in defining characteristic, the natural module is non-algebraic.
openaire +3 more sources
Irredundant bases for finite almost simple groups [PDF]
In this thesis, we study maximum irredundant base sizes I(G, Γ) of three types of finite primitive permutation groups G, where two of the three types are almost simple.
Wu, Peiran
core +1 more source
Most primitive groups are full automorphism groups of edge-transitive hypergraphs [PDF]
, 2014 We prove that, for a primitive permutation group G acting on a set X of size n, other than the alternating group, the probability that Aut (X,YG) = G for a random subset Y of X, tends to 1 as n → ∞.
Cameron, Peter Jephson +2 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On base sizes for actions of finite classical groups
, 2007 Let G be a finite almost simple classical group and let ? be a faithful primitive non-standard G-set. A base for G is a subset B C_ ? whose pointwise stabilizer is trivial; we write b(G) for the minimal size of a base for G.
Timothy C. Burness +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source