Results 81 to 90 of about 1,511,588 (309)

Irredundant bases for finite almost simple groups [PDF]

open access: yes
In this thesis, we study maximum irredundant base sizes I(G, Γ) of three types of finite primitive permutation groups G, where two of the three types are almost simple.
Wu, Peiran
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Contributions to the essential dimension of finite and algebraic groups [PDF]

open access: yes, 2010
Essential dimension, introduced by Joe Buhler and Zinovy Reichstein and in its most general form by Alexander Merkurjev is a measure of complexity of algebraic objects such as quadratic forms, hermitian forms, central simple algebras and étale algebras ...
Lötscher, Roland
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

OD-characterization of almost simple groups related to $L_{2}(49)$ [PDF]

open access: yes, 2008
summary:In the present paper, we classify groups with the same order and degree pattern as an almost simple group related to the projective special linear simple group $L_{2}(49)$.
Shi, Wujie, Zhang, Liangcai
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

On tensor squares of irreducible representations of almost simple groups. I

open access: yesМоделирование и анализ информационных систем, 2011
Almost simple SM_m-groups are considered. A group G is called a SM_m-group if the tensor square of any irreducible representation is decomposed into the sum of its irreducible representations with multiplicities not greater than m.
S. V. Polyakov
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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