Results 101 to 110 of about 10,924,025 (294)
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Embeddings into left-orderable simple groups. [PDF]
J Lond Math Soc, 2022 Darbinyan A, Steenbock M.
europepmc +1 more source
Non-simple localizations of finite simple groups
Journal of Algebra, 2006 10 ...
Rodríguez, José L. +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
On Tensor Squares of Reducible Representations of Almost Simple Groups. II
Моделирование и анализ информационных систем, 2011 Almost simple {SM}_m -groups are considered. A group G is called {SM}_m -group if the tensor square of any irreducible representation is decomposed into the sum of all characters with multiplicities not greater than m.
S. V. Polyakov
doaj
DERANGEMENTS IN SIMPLE AND PRIMITIVE GROUPS [PDF]
, 2003 To appear in Proceedings of Durham Conference on Groups, Geometry, and Combinatorics (2001)
Fulman, Jason, Guralnick, Robert
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On base sizes for actions of finite classical groups
, 2007 Let G be a finite almost simple classical group and let ? be a faithful primitive non-standard G-set. A base for G is a subset B C_ ? whose pointwise stabilizer is trivial; we write b(G) for the minimal size of a base for G.
Timothy C. Burness +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source