Results 91 to 100 of about 5,167,602 (281)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Admissible groups, symmetric factor sets, and simple algebras
International Journal of Mathematics and Mathematical Sciences, 1984 Let K be a field of characteristic zero and suppose that D is a K-division algebra; i.e. a finite dimensional division algebra over K with center K. In Mollin [1] we proved that if K contains no non-trivial odd order roots of unity, then every finite odd
R. A. Mollin
doaj +1 more source
SIMPLE REGULAR SKEW GROUP RINGS [PDF]
Journal of Algebra and Its Applications, 2005 Given a group G acting on a ring R via α:G → Aut (R), one can construct the skew group ring R*αG. Skew group rings have been studied in depth, but necessary and sufficient conditions for the simplicity of a general skew group ring are not known. In this paper, such conditions are given for certain types of skew group rings, with an emphasis on Von ...
openaire +3 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
A Product Theorem in simple Lie groups [PDF]
, 2014 We prove a discretized Product Theorem for general simple Lie groups, in the spirit of Bourgain's Discretized Sum-Product Theorem.Comment: 27 ...
de Saxcé, Nicolas
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Embeddings into left-orderable simple groups. [PDF]
J Lond Math Soc, 2022 Darbinyan A, Steenbock M.
europepmc +1 more source