Results 91 to 100 of about 1,700,341 (334)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
legere discitur legendo: extensive reading in the Latin classroom
The Journal of Classics Teaching, 2019 As a Latin teacher, I think a lot about reading. Without texts I would not have a subject to teach, and the goal of many Latin programs (including my own) is teaching students to read Latin texts.
Andrew Olimpi
doaj +1 more source
Mediality and Rationality in Aristotle's Account of Excellence of Character [PDF]
, 1992 I offer a reading of Aristotle’s “doctrine of the mean” that avoids two pitfalls: taking it as truistic, and taking it as involving the bizarre thesis that whenever one acts as reason directs, one’s action is mid-way between some extremes.
Mccullagh, Mark
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Simple View of Reading Across the Transition from Kindergarten to Grade 1 in a Transparent Orthography [PDF]
, 2023 Gintautas Šilinskas +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Presenting complex ideas using simple syntax in fiction for low-literate immigrant adults [PDF]
, 2012 Manuscript based on this conference presentation Vainikka, A. and M. Young-Scholten. 2012. Presenting complex ideas using simple syntax in fiction for low-literate immigrant adults. Presentation a the Second Language Research Forum, Pittsburgh. October.
Vainikka, Anne Marjatta
core +1 more source
Sexual Orientation and Choice [PDF]
, 2017 Is there a choice in sexual orientation? [Wilkerson, William S. : “Is It a Choice? Sexual Orientation as Interpretation”. In: Journal of Social Philosophy 40. No. 1, p.
Ayala, Saray
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source