Results 51 to 60 of about 1,694,267 (336)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Angles, 2022 A translation is always a process and never a simple one or a complete one. The task of the translator is to transpose meanings allowing distant worlds to make sense of each other but this always bears with itself a dimension of failure as nothing can be
Daniela Vitolo
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
First-Person Knowledge: Wittgenstein, Cavell, and "Therapy" [PDF]
, 2002 The recent publication of The New Wittgenstein signals the arrival of a distinctive "therapeutic" reading of Ludwig Wittgenstein"s philosophical enterprise. As announced in its Preface, this collection presents the "nonsense" of philosophy as the subject
Meyer, Thomas
core
Graphics of the multitude: reading figure and text in Drawing from the City [PDF]
This essay interrogates the question of reading graphic novels from South Asia by proposing the analysis of Drawing from the City, the visual autobiography of Teju Behan, a contemporary artist from Rajasthan. The essay introduces the text and the author,
Menozzi, F
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Prediction of Reading Ability: A Cross-Validation Study of the Simple View of Reading [PDF]
Journal of Literacy Research, 1997 The Simple View of Reading, as originally articulated by Gough and Tunmer (1986), proposes that reading comprehension ability can be predicted by the product term of two components: decoding and listening comprehension (R = D × L). Based on a longitudinal study evaluating developmental reading in bilingual children, Hoover and Gough (1990) reported ...
Ru San Chen, Frank R. Vellutino
openaire +1 more source
The world’s negligence globalisation, philosophy and the misadventures of space [PDF]
, 2016 Las descripciones de nuestra época como un tiempo de desespacialización, desterritorialización y desmaterialización tecnológica merecen ser discutidos con el fin de evidenciar la compleja genealogía de los cambios a los que se refieren.
Marzocca, Ottavio
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source