Results 51 to 60 of about 91,721 (300)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Ab initio modeling of the herpesvirus VP26 core domain assessed by CryoEM density [PDF]

, 2006
Efforts in structural biology have targeted the systematic determination of all protein structures through experimental determination or modeling.
Baker, David, Rixon Frazer J, Baker David, Wedemeyer, W.J., Matthew L Baker, Jiang Wen, Chiu Wah, Baker, M.L., Chiu, Wah, Wah Chiu, Jiang, W., Baker, D., Chiu, W., Baker, Matthew L, Wedemeyer, William J, Rixon, Frazer J, Jiang, Wen, Baker Matthew L, Frazer J Rixon, Rixon, F.J., William J Wedemeyer, David Baker, Wedemeyer William J, Wen Jiang   +23 more
core   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

On application of recurrence formulas of simplex method

Lietuvos Matematikos Rinkinys, 2013
The article analyses a possibility to simplify calculations by using modified recurrence formulas of simplex method for solving problems of linear programming.
Antanas Apynis
doaj   +1 more source

Use of acyclovir for suppression of human immunodeficiency virus infection is not associated with genotypic evidence of herpes simplex virus type 2 resistance to acyclovir: analysis of specimens from three phase III trials.

, 2010
Herpes simplex virus type 2 (HSV-2) is the most common cause of genital ulcer disease and is a cofactor for HIV-1 acquisition and transmission. We analyzed specimens from three separate phase III trials of acyclovir (ACV) for prevention of HIV-1 ...
Kathy Baisley, Clare Tanton, Anna Wald, Rula Green Gladden, Connie Celum, Changalucha, John, Weiss, Helen A, David M. Koelle, Watson-Jones, Deborah, Jairam Lingappa, Helen A. Weiss, Richard J. Hayes, John Changalucha, Celum, Connie, Tanton, Clare, Hayes, Richard J, Deborah Watson-Jones, Gladden, Rula Green, Baisley, Kathy, Koelle, David M, Marshak, Joshua O, Wald, Anna, Lingappa, Jairam, Joshua O. Marshak   +23 more
core   +1 more source

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Bacterial vaginosis in female facility workers in north-western Tanzania: prevalence and risk factors. [PDF]

, 2009
OBJECTIVES: To determine prevalence of, and risk factors for, bacterial vaginosis (BV) among herpes simplex virus (HSV) 2 seropositive Tanzanian women at enrollment into a randomised, placebo-controlled trial of HSV suppressive treatment.
Ross, D, P Hay, Hambleton, Ian, Watson-Jones, Deborah, H A Weiss, D Everett, Tanton, Clare, Watson-Jones, D, J Changalucha, Ross, David, Baisley, Kathy, Weiss, Helen, D Watson-Jones, Hayes, Richard, Everett, Dean, R Hayes, Hambleton, I, K Mugeye, Mugeye, Kokugonza, Weiss, HA, Changalucha, John, Hay, Phillip, Tanton, C, Chirwa, Tobias, D Ross, Changalucha, J, Everett, D, T Chirwa, I Hambleton, K Baisley, Mugeye, K, Baisley, K, Hay, P, C Tanton, Chirwa, T, Hayes, R   +35 more
core   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Automatic optimization method for application plan of absorbing coating

Cailiao gongcheng
Achieving the best wideband stealth performance under the limited weight constraint is the goal pursued in stealth aircraft radar absorbing coating（RAC） application schemes design.
JING Zhi, ZHANG Peng, ZHANG Jian
doaj   +1 more source