Results 31 to 40 of about 195,000 (256)
Applied Sciences, 2022 Triangular meshes play critical roles in many applications, such as numerical simulation and additive manufacturing. However, the triangular meshes transformed from computer-aided design models using common algorithms may have many undesirable narrow ...
Yu Huo +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Directions of Changes in Customs Control
Finanse i Prawo FinansoweThe purpose of the article. In the article, two objectives are indicated: the first – the indication of the specific features of customs control as well as the identification and evaluation of the most important changes within this process with ...
Mirosława Laszuk
doaj +1 more source
Towards Diverse Program Transformations for Program Simplification [PDF]
By reducing the number of lines of code, program simplification reduces code complexity, improving software maintainability and code comprehension. While several existing techniques can be used for automatic program simplification, there is no consensus ...
Tan, S.H. +4 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
An Investigation of Simplification and Cultural Taboos in Mohammad Reza Maraashipour's Translation of Two Novels Written by Naguib Mahfouz Al-Tariq and Zaqaq Al_Medaq [PDF]
پژوهشهای ترجمه در زبان و ادبیات عربی, 2015 Simplification is one of the universal features of translation, and this feature means that translators benefit special techniques to simplify the language of translated text.
Faramarz Mirzaei +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
L. N. Tolstoy on the 20th-Century Estate: From the “Civilization of Machines” to a New Natural House of the Eastern Type [PDF]
Два века русской классикиThe article is devoted to the image of the estate and the house in L. N. Tolstoy’s legacy, especially in his later works. The research indicates that at the turn of the century and in the first decade of the 20th century, Tolstoy became an ardent ...
Valeria G. Andreeva
doaj +1 more source