Results 81 to 90 of about 190,413 (302)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Some Cautions Regarding Tax Simplification

open access: yes, 2015
Although tax simplification enjoys the attractiveness of being the opposite of complexity, it can have untoward effects as illustrated by the examples of a capitation tax, an international income tax regime that lacks rigorous base protection measures ...
Fleming, J. Clifton, Jr.
core  

PLAIN-LANGUAGE APPROACH IN LEGISLATIVE DRAFTING: A PERSPECTIVE FROM POLAND

open access: yesComparative Legilinguistics, 2019
The purpose of this research is to explore plain-language postulates reflecting on legal drafting assumptions since legal acts should be precise, clear and express with no doubts the intention of the legislator.
Natalia ZYCH
doaj   +2 more sources

Does simplification truly exist in translated Chinese? An exploration from a multilingual perspective

open access: yesJoSTrans: The Journal of Specialised Translation
Since the introduction of the translation universal hypothesis, validation efforts have predominantly focused on English and other European languages. However, studies on translated Chinese, particularly those involving language pairs beyond English and
Guo Zhen
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

From Classical Enamel/Dentin Bonding to Self-Adhesive Composites: A Narrative Review of Current Clinical Aspects

open access: yesBioengineering
Adhesive dentistry has undergone a significant evolution, transitioning from classical multi-step adhesives to simplified single-bottle or universal adhesives and now towards self-adhesive composites that no longer require a separate adhesive.
Andreas Rathke   +2 more
doaj   +1 more source

The Sisyphus paradox of cutting red tape and managing public risk<br> The Dutch case

open access: yesUtrecht Law Review, 2008
Cutting red tape has been topical in Dutch debates on legislative politics ever since the beginning of the 1990s, but has gained impetus – since 2003 – in the political arena as the combined consequence of the regulatory reform policies of the Balkenende
Wim J.M. Voermans
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

On Operations in Automatic Text Simplification

open access: yes, 2023
This paper explores the literature of automatic text simplification (ATS) centered on the notion of operations. Operations are the processes of applying certain modifications to a given text in order to transform it.
Cardon, Rémi   +2 more
core  

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