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Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
TEXT COMPLEXITY AND TEXT SIMPLIFICATION [PDF]
, 2012 A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyDue to the fact that emergency situations can lead to substantial losses, both financial and in terms of human lives, it
Temnikova, Irina
core
Towards Diverse Program Transformations for Program Simplification [PDF]
By reducing the number of lines of code, program simplification reduces code complexity, improving software maintainability and code comprehension. While several existing techniques can be used for automatic program simplification, there is no consensus ...
Tan, S.H. +4 more
core +1 more source
On Canonical Forms and Simplification [PDF]
Journal of the ACM, 1970 This paper deals with the simplification problem of symbolic mathematics. The notion of canonical form is defined and presented as a well-defined alternative to the concept of simplified form. Following Richardson it is shown that canonical forms do not exist for sufficiently rich classes of mathematical expressions.
openaire +2 more sources
Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The complexity of tax simplification
, 2016 This book explores the experiences of simplification in a range of countries and ...
James, SR +5 more
core +1 more source
A predictive approach for a real-time remote visualization of large meshes [PDF]
, 2012 Déjà sur HALRemote access to large meshes is the subject of studies since several years. We propose in this paper a contribution to the problem of remote mesh viewing. We work on triangular meshes.
NOUBISSI, Justin-Hervé +4 more
core +1 more source
clara-drew/LCM-simplification: LCM-simplification
, 2021 Simulation files from paper "Simplifying the estimation of diagnostic testing accuracy over time for high specificity tests in the absence of a gold ...
clara-drew
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Directions of Changes in Customs Control
Finanse i Prawo FinansoweThe purpose of the article. In the article, two objectives are indicated: the first – the indication of the specific features of customs control as well as the identification and evaluation of the most important changes within this process with ...
Mirosława Laszuk
doaj +1 more source