Results 71 to 80 of about 158,959 (306)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Surfel Set Simplification With Optimized Feature Preservation
IEEE Access, 2016 In this paper, we propose a novel scheme for simplifying a surfel set with the resultant surfels computed and distributed to preserve prominent geometric and textural features. It works by iteratively collapsing local neighborhoods around surfels until a
Yuxue Fan +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Study of One of Sani al-Molk’s One Thousand and One Night Illustrations From Visual Perception Theory of Gestalt [PDF]
نگره, 2018 General principles of Gestalt School of Psychology (Unified Whole) are codified by a group of German psychologists in early twentieth century. This approach is based on theories describing how the viewer tend to organize a series of simple visual ...
Ameneh Mafitabar +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Role of the Office of Tax Simplification in the United Kingdom and Lessons for Other Countries [PDF]
, 2019 This is the final version. Available from Pretoria University Law Press via the link in this recordWhile simplicity is a desirable feature of a good tax system, simplification is more a slogan than a part of an actual policy agenda in many countries ...
Zu, Y, Oats, L., Zu, Y., Oats, L
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Simplification and arrangement of civil practice / [PDF]
, 1917 No.
New York (State). Legislature. Joint Legislative Committee on the Simplification of Civil Practice.
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Mesh Simplification for Unfolding*
Computer Graphics ForumAbstractWe present a computational approach for unfolding 3D shapes isometrically into the plane as a single patch without overlapping triangles. This is a hard, sometimes impossible, problem, which existing methods are forced to soften by allowing for map distortions or multiple patches.
Manas Bhargava +6 more
openaire +4 more sources