Results 61 to 70 of about 3,382,528 (291)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Structural health monitoring methodology for simply supported bridges: numerical implementation
Revista Facultad de Ingeniería Universidad de Antioquia, 2014 Structural health monitoring of civil structures is currently receiving great amount of attention by researchers due to the economic impact and life-safety implications of early damage detection. Current visual inspection techniques, which aim to detect
Carlos Alberto Riveros Jerez
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Muir String Quartet with Joan Tower, April 27, 2009 [PDF]
, 2009 This is the concert program of the Muir String Quartet with Joan Tower performance on Monday, April 27, 2009 at 7:30 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts. Works performed were String Quartet No.
School of Music, Boston University
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
SIMPLY SUPPORTED BEAM RESPONSE ON ELASTIC FOUNDATION CARRYING REPEATED ROLLING CONCENTRATED LOADS [PDF]
Journal of Engineering Science and Technology, 2010 The response of a simply-supported beam on elastic foundation to repeated moving concentrated loads is obtained by means of the Fourier sine transformation.
SHAHIN NAYYERI AMIRI, MBAKISYA ONYANGO
doaj
Eigenvibrations of a simply supported beam with elastically attached load
MATEC Web of Conferences, 2018 The nonlinear differential eigenvalue problem describing eigenvibrations of a simply supported beam with elastically attached load is investigated. The existence of an increasing sequence of positive simple eigenvalues with limit point at infinity is ...
Samsonov Anton A. +2 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source