Results 81 to 90 of about 3,382,528 (291)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A buckling analysis for rectangular orthotropic plates with centrally located cutouts [PDF]
An analysis to obtain the buckling loads of a rectangular orthotropic plate with a centrally located cutout is described. Cutout shapes can be elliptical, circular, rectangular, or square.
Nemeth, M. P.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Journal of Mechanical Engineering, 2019 This paper shows an analysis of the free vibration of functionally graded simply supported nanoplate. The nonlocal four variables shear deformation plate theory is used to predict the free vibration frequencies of functionally graded nanoplate simply ...
Abdelbaki Chikh
doaj +1 more source
An investigation of dynamic instability of stiffened rectangular plates [PDF]
Boundaries of regions of parametric instability of simply supported stiffened rectangular ...
Duffield, R. C., Willems, N.
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Ultimate strength of simply supported plate with opening under uniaxial compression
International Journal of Naval Architecture and Ocean Engineering, 2012 Unstiffened plates are integral part of all kinds of structures such as ship and offshore oil platforms. Openings are unavoidable and absolutely reduce the ultimate strength of structures.
Chang-Li Yu, Joo-Sung Lee
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Numerical analysis and parametric studies of the buckling of composite orthotropic compression and shear panels [PDF]
A computer program is presented which was developed for the combined compression and shear of stiffened variable thickness orthotropic composite panels on discrete springs: boundary conditions are general and include elastic boundary restraints. Buckling
Housner, J. M., Stein, M.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source