Results 241 to 250 of about 1,152,910 (296)

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Coffee pulp simulated digestion enhances its in vitro ability to decrease emulsification and digestion of fats, and attenuates lipid accumulation in HepG2 cell model. [PDF]

Curr Res Food Sci
Braojos C, Rebollo-Hernanz M, Cañas S, Aguilera Y, Gil-Ramírez A, Martín-Cabrejas MA, Benítez V.   +6 more
europepmc   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Milk digestion peptidomics: Tracking caseinophosphopeptides in simulated gastrointestinal digestion

Food Bioscience, 2019
Abstract The dynamics of caseinophosphopeptides (CPP) in simulated gastrointestinal digestion was studied. CPP in the undigested milk and in vitro simulated gastrointestinal hydrolysates were enriched using immobilized titanium(IV) ion affinity chromatography (Ti4+-IMAC) beads and measured using liquid chromatography-tandem mass spectrometry.
Yan Jin
exaly   +3 more sources

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52  Evaluation of barley digestibility with an in vitro total tract digestion simulation

Journal of Equine Veterinary Science, 2021
Methods of investigating the digestibility of horse feeds have focused on the hindgut fermentation of feedstuffs, neglecting the foregut digestibility. The aim of this study was to evaluate the foregut digestibility and hindgut fermentation of barley in vitro.
V. Farci, J.-A. Murray, P. Hastie
openaire   +1 more source

Dynamic simulator for anaerobic digestion processes

Biotechnology and Bioengineering, 1982
AbstractA transient, two‐culture model simulating methane production from biomass has been developed. The simulator, based partially on the work by Andrews and McCarty, is capable of calculating the hydrolysis products of several common organic materials, accommodating various substrate feeding modes, and simulating the transient physico‐biochemical ...
C, Kleinstreuer, T, Poweigha
openaire   +2 more sources

CFD simulation of mixing in anaerobic digesters

Bioresource Technology, 2009
A three-dimensional CFD model incorporating the rheological properties of sludge was developed and applied to quantify mixing in a full-scale anaerobic digester. The results of the model were found to be in good agreement with experimental tracer response curve.
Mitsuharu, Terashima, Rajeev, Goel, Kazuya, Komatsu, Hidenari, Yasui, Hiroshi, Takahashi, Y Y, Li, Tatsuya, Noike   +6 more
openaire   +2 more sources