Results 51 to 60 of about 953,722 (278)

Table_1_Simulated Weightlessness Perturbs the Intestinal Metabolomic Profile of Rats.docx

, 2019
Recently, disorders of intestinal homeostasis in the space environment have been extensively demonstrated. Accumulating evidence have suggested microgravity and simulated weightlessness could induce dysbiosis of intestinal microbiota, which may ...
Mingliang Jin (1943671), Jiaojiao Wang (541548), Hongbin Zhou (586601), Ke Zhao (248186), Hao Zhang (15339)   +4 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Image_1_Simulated Weightlessness Perturbs the Intestinal Metabolomic Profile of Rats.JPEG

, 2019
Recently, disorders of intestinal homeostasis in the space environment have been extensively demonstrated. Accumulating evidence have suggested microgravity and simulated weightlessness could induce dysbiosis of intestinal microbiota, which may ...
Mingliang Jin (1943671), Jiaojiao Wang (541548), Hongbin Zhou (586601), Ke Zhao (248186), Hao Zhang (15339)   +4 more
core   +1 more source

Simulated Weightlessness Effect on Ovarian Follicular Structure and Estradiol Levels in Rats [PDF]

Iranian South Medical Journal
Background: Long-term human habitation in space, enabled by advances in space travel, may impair the function of various physiological systems. Given the critical need to maintain astronauts’ health during and after missions, this study investigated the ...
Maryam Salavatifar, Amirreza Joorabli, Nasim Hayati Roodbari   +2 more
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Table_2_Simulated Weightlessness Perturbs the Intestinal Metabolomic Profile of Rats.docx

, 2019
Recently, disorders of intestinal homeostasis in the space environment have been extensively demonstrated. Accumulating evidence have suggested microgravity and simulated weightlessness could induce dysbiosis of intestinal microbiota, which may ...
Mingliang Jin (1943671), Jiaojiao Wang (541548), Hongbin Zhou (586601), Ke Zhao (248186), Hao Zhang (15339)   +4 more
core   +1 more source

Effect of Electroacupuncture Intervention at Different Time-points on Levels of HSP 70,MDA,SOD and GSH-PX of Liver in Rats with Simulated Weightlessness

针刺研究, 2015
Objective To observe the effect of acupuncture intervention at different time-points on the activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),the content of malonaldehyde(MDA)and expression of heat shock protein 70(HSP 70)of liver ...
SONG Yan, ZHAO Guo-zhen, ZHAO Bai-xiao, JI Bo, WANG De-sheng, ZHANG He, MAO Ying-qiu, ZHANG Ping, XU Yong-si, LIU Ya-li, LU Ya-wen, DAI Jian, LI Ying-hui   +12 more
doaj   +2 more sources

Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

Applied Sciences, 2020
Changes in cell–matrix and cell-to-cell adhesion patterns are dramatically fostered by the microgravity exposure of living cells. The modification of adhesion properties could promote the emergence of a migrating and invasive phenotype.
Giulia Ricci, Alessandra Cucina, Sara Proietti, Simona Dinicola, Francesca Ferranti, Marcella Cammarota, Antonio Filippini, Mariano Bizzarri, Angela Catizone   +8 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source