Results 91 to 100 of about 2,707,349 (312)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A quantitative model of hierarchical product design

Design Science
Analysing hierarchical design processes is difficult due to the technical and organizational dependencies spanning over multiple levels. The V-Model of Systems Engineering considers multiple levels. It is, however, not quantitative.
Ferdinand Wöhr, Simon Königs, Max Stanglmeier, Markus Zimmermann   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Distinguishing simulation games from simulators by considering design characteristics

, 2005
The advent of powerful personal computers has made it possible for home users to experience simulation technology through Simulation Games (a.k.a. Sims).
Wong, K.W., Depickere, A., Fung, C.C., Narayanasamy, V.   +3 more
core  

Analysis and Simulation on Energy Performance Based Design

Megaron, 2011
The definition of sustainability varies depending on the sector to which it is related. In the building sector, sustainability mainly covers “high performance building” requirements.
Gülsu ULUKAVAK HARPUTLUGİL
doaj  

The 2024 French guidelines for scenario design in simulation-based education: manikin-based immersive simulation, simulated participant-based immersive simulation and procedural simulation

Medical Education Online
Background Simulation-based education in healthcare encompasses a wide array of modalities aimed at providing realistic clinical experiences supported by meticulously designed scenarios. The French-speaking Society for Simulation in Healthcare (SoFraSimS)
Guillaume Der Sahakian, Maxime de Varenne, Clément Buléon, Guillaume Alinier, Christian Balmer, Antonia Blanié, Bertrand Bech, Anne Bellot, Hamdi Boubaker, Nadège Dubois, Francisco Guevara, Erwan Guillouet, Jean-Claude Granry, Morgan Jaffrelot, François Lecomte, Fernande Lois, Mohammed Mouhaoui, Ollivier Ortolé, Méryl Paquay, Justine Piazza, Marie Pittaco, Patrick Plaisance, Dan Benhamou, Gilles Chiniara, Etienne Rivière   +24 more
doaj   +1 more source

DFT Simulation-Based Design of 1T-MoS₂ Cathode Hosts for Li-S Batteries and Experimental Evaluation. [PDF]

Int J Mol Sci, 2022
Hojaji E, Andritsos EI, Li Z, Chhowalla M, Lekakou C, Cai Q.   +5 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Simulation-based design study for the passive shielding of the COSINUS dark matter experiment. [PDF]

Eur Phys J C Part Fields, 2022
Angloher G, Dafinei I, Marco ND, Ferroni F, Fichtinger S, Filipponi A, Friedl M, Fuss A, Ge Z, Heikinheimo M, Huitu K, Maji R, Mancuso M, Pagnanini L, Petricca F, Pirro S, Pröbst F, Profeta G, Puiu A, Reindl F, Schäffner K, Schieck J, Schmiedmayer D, Schwertner C, Stahlberg M, Stendahl A, Wagner F, Yue S, Zema V, Zhu Y, (The COSINUS Collaboration), Pandola L.   +31 more
europepmc   +1 more source