Results 31 to 40 of about 2,707,349 (312)

Simulation-based learning tool for facilities design [PDF]

open access: yesProceedings of the 28th conference on Winter simulation - WSC '96, 1996
This paper describes a tool, LAYSIM, to emphasize to the students the important role of material handling cost in choosing the type of layout; i.e., Product, Jobshop or Group Technology-based layout for a certain set of products. It addresses how through experimentation with LAYSIM students understand and appreciate the manufacturing costs associated ...
Bala Ram, Rajiv Girdhar
openaire   +1 more source

Hybrid Ship Design Optimization Framework Integrating a Dual-Mode CFD–Surrogate Mechanism

open access: yesApplied Sciences
Reducing hydrodynamic resistance remains a central concern in modern ship design. The Simulation-Based Design technique offers high-fidelity optimization through computational fluid dynamics, but this comes at the cost of computational efficiency.
Yicun Dong, Lin Du, Guangnian Li
doaj   +1 more source

A metamorphic controller for plant control system design [PDF]

open access: yesModeling, Identification and Control, 2016
One of the major problems in the design of industrial control systems is the selection and parameterization of the control algorithm. In practice, the most common solution is the PI (proportional-integral) controller, which is simple to implement, but is
Tomasz Klopot   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Simulation-based impact analysis for sustainable manufacturing design and management [PDF]

open access: yes, 2018
This research focuses on effective decision-making for sustainable manufacturing design and management. The research contributes to the decision-making tools that can enable sustainability analysts to capture the aspects of the economic, environmental ...
Gbededo, Mijoh Ayodele
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A Simulation Model Design Method for Cloud-Based Simulation Environment

open access: yesAdvances in Mechanical Engineering, 2013
Simulation technologies provide necessary validation tools for the conceptual design of complex products involving multiple disciplines. A variety of simulation models are developed in specific organizations or enterprises to verify the design plan ...
Chunsheng Hu   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Overview of AI-Assisted Design-on-Simulation Technology for Reliability Life Prediction of Advanced Packaging

open access: yes, 2021
Several design parameters affect the reliability of wafer-level type advanced packaging, such as upper and lower pad sizes, solder volume, buffer layer thickness, and chip thickness, etc.
Bo-Ruei Lai   +3 more
core   +1 more source

Behavioral model composition in simulation-based design [PDF]

open access: yesProceedings 35th Annual Simulation Symposium. SS 2002, 2003
We present a simulation and design framework for simultaneously designing and modeling electromechanical systems. By instantiating component objects and connecting them to each other via ports, a designer can configure complex systems. This configuration information is then used to automatically generate a corresponding system-level simulation model ...
Sinha, Rajarishi   +2 more
openaire   +1 more source

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