Results 41 to 50 of about 2,707,349 (312)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Combining Axiomatic Design and Case-Based Reasoning in a Design Methodology of Mechatronics Products [PDF]

, 2009
Organised by: Cranfield UniversityCurrent market environments are volatile and unpredictable. The ability for design products to meet customer’s requirements has become critical to success.
Janthong, N., Brissaud, D., Janthong, Nattawut, Butdee, S., Butdee, Suthep, Brissaud, Daniel   +5 more
core  

Simulation design of automobile automatic clutch based on mechatronics

Journal of Intelligent Systems, 2022
This article aims to study the simulation and design of automobile automatic clutch under mechatronics. A new control strategy for the automatic clutch of the electromagnetic transmission is proposed.
Chen Chao, Hernández Danaysa Macías, Martinez Silega Nemuri   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Analysing discrete event simulation modelling activities applied in manufacturing system design [PDF]

, 2009
Organised by: Cranfield UniversityIn manufacturing industry, Discrete Event Simulation (DES) is applied in just a small fraction of the cases where it could give significant value. The complexity of the DES technology itself is one barrier to achieving
Johansson, J.
core  

Simulation-Based Education to Improve Hand Hygiene Practices: A Pilot Study in Sub-Saharan Africa

Hygiene
Hand hygiene is a key measure to prevent healthcare-associated infections (HAIs), yet compliance remains low in Sub-Saharan Africa (SSA), due to limited resources, insufficient training, and behavioral challenges.
Paula Rocha, Stephanie Norotiana Andriamiharisoa, Ana Catarina Godinho, Pierana Gabriel Randaoharison, Lugie Harimalala, Lova Narindra Randriamanantsoa, Oni Zo Andriamalala, Emmanuel Guy Raoelison, Jane Rogathi, Paulo Kidayi, Christina Mtuya, Rose Laisser, Eyeshope J. Dausen, Pascalina Nzelu, Barbara Czech-Szczapa, Edyta Cudak-Kasprzak, Marlena Szewczyczak, João Graveto, Pedro Parreira, Sofia Ortet, M. Rosário Pinto   +20 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The rapid design of simulation models using cladistics and template based modelling [PDF]

, 2012
The drive towards a more globally competitive market has led to an increase in demand for goods and services on a global scale. As a result of this increase in productivity, production systems are being designed and redesigned at an increased rate and ...
Rampersad, Kevin
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