Results 61 to 70 of about 2,707,349 (312)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Design and discrete event simulation of power and free handling systems [PDF]
, 1997 Effective manufacturing systems design and implementation has become increasingly critical, with the reduction in manufacturing product lead times, and the subsequent influence on engineering projects.
Lynn, Jeffrey Alexander
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
BuildingsThe urban design process is complex and interdisciplinary, especially in the context of high-density cities with high-rise buildings. The design of high-rise buildings requires input from a variety of stakeholders in the city, who often represent ...
Peng Du, Geoffrey Little, Erick Romero
doaj +1 more source
Evidence-Centered Design for Simulation-Based Assessment [PDF]
Military Medicine, 2013 Simulations provide opportunities for people to learn and to develop skills for situations that are expensive, time-consuming, or dangerous. Careful design can support their learning by tailoring the features of situations to their levels of skill, allowing repeated attempts, and providing timely feedback.
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Simulation of Reactive Fluoropolymer-Based Material Penetrator
It is very important to solve the numerical simulation of fluoropolymer-based reactive materials in the process of engineering design. Although custom development techniques are rapidly being applied to numerical simulation problems of reactive materials,
Peiyu Li +4 more
core +1 more source
Building pedestrian simulation and channel design simulation technology based on virtual reality technology [PDF]
Archives of Civil EngineeringIn recent years, virtual reality technology has been widely applied and researched in various fields. In digital architectural design and simulation, it has gradually become an important tool.
Xiangling Luo, Mingyang Liu
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Design project planning, monitoring and re-planning through process simulation
, 2009 Effective management of design schedules is a major concern in industry, since timely project delivery can have a significant influence on a company’s profitability.
P John Clarkson, David C Wynn
core