Results 91 to 100 of about 6,077,636 (282)

Population Pharmacokinetics of Bepirovirsen in Healthy Participants and Participants with Chronic Hepatitis B Virus Infection: Results from Phase 1, 2a, and 2b Studies

Infectious Diseases and Therapy
Introduction Bepirovirsen is a novel antisense oligonucleotide in development for chronic hepatitis B virus (HBV) infection therapy. Understanding the impact that clinical characteristics may have on bepirovirsen exposure is important for determining ...
Amir S. Youssef, Mohamed Ismail, Kelong Han, Mindy Magee, Ahmed Nader   +4 more
doaj   +1 more source

Vortexje - An Open-Source Panel Method for Co-Simulation [PDF]

, 2013
This paper discusses the use of the 3-dimensional panel method for dynamical system simulation. Specifically, the advantages and disadvantages of model exchange versus co-simulation of the aerodynamics and the dynamical system model are discussed.
Baayen, Jorn H.
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Federated Simulations [PDF]

, 2016
The integration of simulation components into a federated, interoperable simulation environment introduces a large number of engineering challenges. Many of these challenges are technical issues, but there are also several challenges from the project management perspective. For example, when simulation components are provided by different organizations
Huiskamp, W., Berg, T. van den
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Modeling and simulation of data communication networks using SARA [PDF]

, 1985
The selection of an appropriate simulation language can have a profound impact on the success of a simulation study. The available options range from domain-specific simulation languages to general-purpose programming languages. These languages are often
Razouk, Rami R.
core   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Simulation Study of Corrosion Product Removal Behavior by Mixed-Bed Ion Exchange Columns in PWRs

Science and Technology of Nuclear Installations
In order to reduce the negative impact of corrosion products on the operation of pressurized water reactors (PWRs) and to provide support for the operation and failure analysis of the purification resin in the first circuit of the PWRs, this paper takes ...
Shiyu Tan, Haiyan Xie, Shuang Chen, Ke Wang, Shitao Liu, Dongyun Li, Jing Li, Yang Gao, Hongguo Hou, Caishan Jiao, Nan Chao, Tingting Liu, Yu Zhou   +12 more
doaj   +1 more source

Digital receiver simulation [PDF]

, 1974
Digital simulation of the data link for the Saturn-Uranus spacecraft design is summarized. The data link is a 40 watt, 400 MegaHertz, 44 bit-a-second link, a power starved link, and uses convolution coding.
Hinrichs, C.
core   +1 more source